Document Detail

BAFF, APRIL, TWE-PRIL: who's who?
MedLine Citation:
PMID:  18295728     Owner:  NLM     Status:  MEDLINE    
BAFF and APRIL are two members of the TNF superfamily that have co-stimulatory activity on B cells and contribute to autoimmunity. While BAFF is processed at the cell surface, APRIL is processed inside the cell by a furin-convertase and is able to perform its function only as a soluble factor. However, APRIL can be expressed as a cell surface fusion protein with TWEAK called TWE-PRIL. BAFF can also exist as a soluble molecule and can be detected in human serum. Whether the biological functions controlled by membrane-bound BAFF differ from those triggered by soluble BAFF is unclear. In addition to this complexity, DeltaBAFF, an alternative splice isoform of BAFF shows different properties. BAFF can also, in autoimmune disease form heterotrimers with APRIL but the control and function of these heterotrimers remain unclear. In order to understand the function of these molecules we need to elucidate the complexity of the various forms of these members of the TNF family.
Capucine Daridon; Pierre Youinou; Jacques-Olivier Pers
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Publication Detail:
Type:  Journal Article; Review     Date:  2007-06-21
Journal Detail:
Title:  Autoimmunity reviews     Volume:  7     ISSN:  1568-9972     ISO Abbreviation:  Autoimmun Rev     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-25     Completed Date:  2008-07-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101128967     Medline TA:  Autoimmun Rev     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  267-71     Citation Subset:  IM    
Department of Immunopathology, Brest University Medical School, Brest, France.
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MeSH Terms
Autoimmune Diseases / immunology,  metabolism
B-Cell Activating Factor / chemistry,  genetics,  metabolism*
B-Lymphocytes / metabolism*
Protein Binding
Tumor Necrosis Factor Ligand Superfamily Member 13 / chemistry,  genetics,  metabolism*
Tumor Necrosis Factors / chemistry,  genetics,  metabolism*
Reg. No./Substance:
0/B-Cell Activating Factor; 0/TNFSF12 protein, human; 0/TNFSF13 protein, human; 0/Tumor Necrosis Factor Ligand Superfamily Member 13; 0/Tumor Necrosis Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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