Document Detail


BACE1 levels correlate with phospho-tau levels in human cerebrospinal fluid.
MedLine Citation:
PMID:  23566348     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Previous studies have investigated the activity and protein levels of BACE1, the β-secretase, in the brain and cerebrospinal fluid (CSF) of Alzheimer's disease (AD) patients, however, results remain contradictory. We present here a highly specific and sensitive BACE1 ELISA, which allows measuring accurately BACE1 levels in human samples. We find that BACE1 levels in CSF of AD patients and other neurological disorder (OND) patients are slightly increased when compared to those of a non-neurological disorder control group (NND). BACE1 levels in CSF were well correlated with total-tau and hyperphosphorylated tau levels in the CSF, suggesting that the recorded alterations in BACE1 levels correlate with cell death and neurodegeneration.
Authors:
Soraia Barao; Lujia Zhou; Katarzyna Adamczuk; Tine Vanhoutvin; Fred van Leuven; David Demedts; Anne-Catherine Vijverman; Xavier Bossuyt; Rik Vandenberghe; Bart De Strooper
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Current Alzheimer research     Volume:  10     ISSN:  1875-5828     ISO Abbreviation:  Curr Alzheimer Res     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-08-23     Completed Date:  2014-04-08     Revised Date:  2014-04-29    
Medline Journal Info:
Nlm Unique ID:  101208441     Medline TA:  Curr Alzheimer Res     Country:  United Arab Emirates    
Other Details:
Languages:  eng     Pagination:  671-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Alzheimer Disease / cerebrospinal fluid*,  diagnosis*
Amyloid Precursor Protein Secretases / biosynthesis,  cerebrospinal fluid*,  chemistry
Animals
Aspartic Acid Endopeptidases / biosynthesis,  cerebrospinal fluid*,  chemistry
Biological Markers / cerebrospinal fluid
Female
HEK293 Cells
Humans
Male
Mice
Mice, Knockout
Nervous System Diseases / cerebrospinal fluid,  diagnosis
Phosphorylation / physiology
Protein Structure, Secondary
Single-Blind Method
tau Proteins / cerebrospinal fluid*,  chemistry
Chemical
Reg. No./Substance:
0/Biological Markers; 0/tau Proteins; EC 3.4.-/Amyloid Precursor Protein Secretases; EC 3.4.23.-/Aspartic Acid Endopeptidases; EC 3.4.23.46/BACE1 protein, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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