Document Detail


B7 costimulation and autoantigen specificity enable B cells to activate autoreactive T cells.
MedLine Citation:
PMID:  8816398     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study examines the role of B cells as auto-APCs in activating autoimmune T cells responses. Mice immunized with their own cytochrome c (cyt c) elicit no detectable B or T cell responses. However, mice first primed with a cryptic self peptide, mouse cyt c 81-104, followed at 3 wk with a boost of whole cyt c, elicit autoreactive T cells specific to self cyt c. T cell autoimmunity is not elicited in similarly immunized B cell-deficient (mu MT) mice. The expression of the B7-2 and/or B7-1 costimulatory molecules, as well as specificity to a self Ag, cyt c, enabled B cells to activate T cells to proliferate and to express IFN-gamma, IL-4, IL-5, and IL-10 cytokine mRNAs. In contrast, neither adoptively transferred B7- B cells nor nonspecific B7+ B cells were able to activate naive T cells. Moreover, anti-B7-2 treatment of mice prevented the in vivo expression of the IL-4, IL-5, and IFN-gamma cytokine mRNA responses. Our results suggest a major role of autoantigen-specific, B7-bearing B cells in breaking T cell tolerance to self Ag.
Authors:
R Roth; T Nakamura; M J Mamula
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  157     ISSN:  0022-1767     ISO Abbreviation:  J. Immunol.     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1996-11-25     Completed Date:  1996-11-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2924-31     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, Yale University School of Medicine, New Haven, CT 06520-8031, USA.
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MeSH Terms
Descriptor/Qualifier:
Adoptive Transfer
Animals
Antibodies, Monoclonal / pharmacology
Antigen Presentation*
Antigens, CD / immunology
Antigens, CD80 / immunology*
Antigens, CD86
Autoantigens / immunology*
Autoimmunity / immunology*
B-Lymphocytes / immunology*,  transplantation
Base Sequence
Cell Movement
Cytochrome c Group / immunology
Cytokines / biosynthesis,  genetics
Female
Gene Expression Regulation
Immunization
Lymph Nodes / immunology
Lymphocyte Activation*
Membrane Glycoproteins / immunology
Mice
Molecular Sequence Data
Peptide Fragments / immunology
Polymerase Chain Reaction
RNA, Messenger / biosynthesis
Rats
Self Tolerance
Signal Transduction / physiology
T-Lymphocyte Subsets / immunology*
Grant Support
ID/Acronym/Agency:
AI36529/AI/NIAID NIH HHS; AR41032/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antigens, CD; 0/Antigens, CD80; 0/Antigens, CD86; 0/Autoantigens; 0/Cd86 protein, mouse; 0/Cd86 protein, rat; 0/Cytochrome c Group; 0/Cytokines; 0/Membrane Glycoproteins; 0/Peptide Fragments; 0/RNA, Messenger

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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