| B7 family molecules as regulators of the maternal immune system in pregnancy. | |
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MedLine Citation:
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PMID: 20384620 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Placental and fetal growth and development are associated with chronic exposure of the maternal immune system to fetally derived, paternally inherited antigens. Because maternal lymphocytes are aware of fetal antigens, active tolerance mechanisms are required to ensure unperturbed progression of pregnancy and delivery of a healthy newborn. These mechanisms of tolerance may include deletion, receptor downregulation, and anergy of fetal antigen-specific cells in lymphoid tissues, as well as regulation at the maternal-fetal interface by a variety of locally expressed immunoregulatory molecules. The B7 family of costimulatory molecules comprises one group of immunoregulatory molecules present in the decidua and placenta. B7 family members mediate both inhibitory and stimulatory effects on T-cell activation and effector functions and may play a critical role in maintaining tolerance to the fetus. Here, we review the known functions of the B7 family proteins in pregnancy. |
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Authors:
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Margaret G Petroff; Antoine Perchellet |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2010-04-08 |
Journal Detail:
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Title: American journal of reproductive immunology (New York, N.Y. : 1989) Volume: 63 ISSN: 1600-0897 ISO Abbreviation: Am. J. Reprod. Immunol. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-22 Completed Date: 2010-10-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8912860 Medline TA: Am J Reprod Immunol Country: Denmark |
Other Details:
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Languages: eng Pagination: 506-19 Citation Subset: IM |
Affiliation:
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Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA. mpetroff@kumc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, CD80 / immunology*, metabolism Decidua / immunology Female Fetus / immunology Humans Immune System / immunology* Immune Tolerance Lymphocyte Activation / immunology Male Maternal-Fetal Exchange / immunology* Mice Mice, Inbred C57BL Mice, Inbred CBA Placenta / cytology Pregnancy T-Lymphocytes / immunology |
| Grant Support | |
ID/Acronym/Agency:
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P01 HD049480/HD/NICHD NIH HHS; P20 RR16475/RR/NCRR NIH HHS; R01 HD045611/HD/NICHD NIH HHS; T32HD007455/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD80 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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