Document Detail

B1 kinin receptor activity in pigs is associated with pre-existing infection.
MedLine Citation:
PMID:  9776478     Owner:  NLM     Status:  MEDLINE    
Bradykinin (BK) and related kinins are potent inflammatory mediators produced during acute and chronic inflammation. The effects of these kinins are mediated via the stimulation of either a B2 or a B1 receptor. The B1 receptor is not normally present but its expression can be induced within 4 h by a variety of noxious stimuli, specifically, gram-negative bacteria or bacterial lipopolysaccharide (LPS) given to healthy animals. This study compared the cardiovascular response of healthy pigs and pigs diagnosed with a pre-existing spontaneously acquired infection to BK, a B2 receptor agonist, and des-Arg9-BK, a B1 receptor agonist. Eighty-eight percent of the animals diagnosed with an established infection based on a standardized clinical evaluation demonstrated increased sensitivity and responsiveness to des-Arg9-BK but normal responsiveness to BK and acetylcholine. In contrast, only 15% of healthy animals showed elevated responses to des-Arg9-BK. The response to des-Arg9-BK and BK in each group was characterised as B1 and B2, respectively, using the selective B1 and B2 antagonists Lys0-Leu8-des-Arg9-BK and Hoe 140, respectively. This study demonstrates the existence and function of the B1 receptor in animals with a previously acquired infection. These observations lend validity to animal experiments with LPS infusion in order to model bacterial inflammation.
M Siebeck; M Schorr; E Spannagl; M Lehner; H Fritz; J C Cheronis; E T Whalley
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Immunopharmacology     Volume:  40     ISSN:  0162-3109     ISO Abbreviation:  Immunopharmacology     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-12-17     Completed Date:  1998-12-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902474     Medline TA:  Immunopharmacology     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  49-55     Citation Subset:  IM    
Department of Surgery, Klinikum Innenstadt, Ludwig-Maximilians University, Munich, Germany.
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MeSH Terms
Acetylcholine / pharmacology
Bacterial Infections / etiology,  metabolism*
Blood Pressure / drug effects
Bradykinin / analogs & derivatives,  pharmacology
Gram-Negative Bacteria
Heart Rate / drug effects
Receptor, Bradykinin B1
Receptor, Bradykinin B2
Receptors, Bradykinin / agonists*,  antagonists & inhibitors
Reg. No./Substance:
0/Lipopolysaccharides; 0/Receptor, Bradykinin B1; 0/Receptor, Bradykinin B2; 0/Receptors, Bradykinin; 130308-48-4/icatibant; 15958-92-6/bradykinin, des-Arg(9)-; 51-84-3/Acetylcholine; 58-82-2/Bradykinin; 64695-06-3/bradykinin, Leu(8)-des-Arg(9)-

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