| B vitamins deficiency and decreased anti-oxidative state in patients with liver cancer. | |
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MedLine Citation:
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PMID: 17571208 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: This study examined the status of oxidative stress and B vitamins in hepatocellular carcinoma (HCC) patients in different tumor-node-metastasis stages. Patients were divided into two groups as I + II (n = 21) and III + IV (n = 19). METHODS: Plasma levels of lipid oxidation, alpha-tocopherol, beta-carotene, vitamin C, glutathione and the activity of antioxidant enzymes (glutathione peroxidase, superoxide dismutase, catalase, and xanthine oxidase) were determined for evaluating oxidative status. Blood B vitamins (B(1), B(2), B(6), B(12), and folate) and serum ghrelin were analyzed, and the relationship between serum ghrelin and vitamins B(2) (or B(6)) was evaluated. RESULTS: HCC patients at III + IV stage showed significantly lower ghrelin, higher cholesterol, triglyceride, and uric acid than patients at I + II stage and healthy subjects (P < 0.05). Plasma lipid oxidation level in HCC patients was significantly greater than healthy subjects (P < 0.05). The activity of glutathione peroxidase, superoxide dismutase or catalase was significantly decreased, but xanthine oxidase activity was significantly elevated in HCC patients (P < 0.05). Plasma level of glutathione and vitamin C, not alpha-tocopherol and beta-carotene, in HCC patients was significantly lower (P < 0.05). Vitamins B(2) and B(6) levels in red blood cells from these HCC patients were significantly lower (P < 0.05). CONCLUSION: This study provided novel clinical findings regarding the status of oxidative stress and B vitamins in HCC patients. Plasma glutathione level may be a proper biomarker for evaluating oxidative status for HCC patients. Our data indicate that HCC patients might need B vitamins supplementation. The increased serum level of triglyceride and cholesterol might be a consequence of an impaired hepatic fat metabolism, and might be improved by a lower fat administration to these patients. |
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Authors:
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Chun-che Lin; Mei-chin Yin |
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Publication Detail:
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Type: Journal Article Date: 2007-06-14 |
Journal Detail:
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Title: European journal of nutrition Volume: 46 ISSN: 1436-6207 ISO Abbreviation: Eur J Nutr Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-07-26 Completed Date: 2007-10-11 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100888704 Medline TA: Eur J Nutr Country: Germany |
Other Details:
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Languages: eng Pagination: 293-9 Citation Subset: IM |
Affiliation:
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Dept. of Internal Medicine, Chung Shan Medical University Hospital, No. 110, Sec. 1, Chien Kuo N. Rd, Taichung, 402, Taiwan, ROC. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Antioxidants / metabolism* Biological Markers / blood Carcinoma, Hepatocellular / blood*, metabolism Case-Control Studies Female Ghrelin Glutathione / blood Humans Lipid Metabolism Lipid Peroxidation Liver Neoplasms / blood*, metabolism Male Middle Aged Neoplasm Staging Oxidation-Reduction Oxidative Stress* Peptide Hormones / blood Vitamin B Complex / blood* Vitamin B Deficiency / blood*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Biological Markers; 0/Ghrelin; 0/Peptide Hormones; 12001-76-2/Vitamin B Complex; 70-18-8/Glutathione |
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