Document Detail

B vitamins deficiency and decreased anti-oxidative state in patients with liver cancer.
MedLine Citation:
PMID:  17571208     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: This study examined the status of oxidative stress and B vitamins in hepatocellular carcinoma (HCC) patients in different tumor-node-metastasis stages. Patients were divided into two groups as I + II (n = 21) and III + IV (n = 19). METHODS: Plasma levels of lipid oxidation, alpha-tocopherol, beta-carotene, vitamin C, glutathione and the activity of antioxidant enzymes (glutathione peroxidase, superoxide dismutase, catalase, and xanthine oxidase) were determined for evaluating oxidative status. Blood B vitamins (B(1), B(2), B(6), B(12), and folate) and serum ghrelin were analyzed, and the relationship between serum ghrelin and vitamins B(2) (or B(6)) was evaluated. RESULTS: HCC patients at III + IV stage showed significantly lower ghrelin, higher cholesterol, triglyceride, and uric acid than patients at I + II stage and healthy subjects (P < 0.05). Plasma lipid oxidation level in HCC patients was significantly greater than healthy subjects (P < 0.05). The activity of glutathione peroxidase, superoxide dismutase or catalase was significantly decreased, but xanthine oxidase activity was significantly elevated in HCC patients (P < 0.05). Plasma level of glutathione and vitamin C, not alpha-tocopherol and beta-carotene, in HCC patients was significantly lower (P < 0.05). Vitamins B(2) and B(6) levels in red blood cells from these HCC patients were significantly lower (P < 0.05). CONCLUSION: This study provided novel clinical findings regarding the status of oxidative stress and B vitamins in HCC patients. Plasma glutathione level may be a proper biomarker for evaluating oxidative status for HCC patients. Our data indicate that HCC patients might need B vitamins supplementation. The increased serum level of triglyceride and cholesterol might be a consequence of an impaired hepatic fat metabolism, and might be improved by a lower fat administration to these patients.
Chun-che Lin; Mei-chin Yin
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Publication Detail:
Type:  Journal Article     Date:  2007-06-14
Journal Detail:
Title:  European journal of nutrition     Volume:  46     ISSN:  1436-6207     ISO Abbreviation:  Eur J Nutr     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-26     Completed Date:  2007-10-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100888704     Medline TA:  Eur J Nutr     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  293-9     Citation Subset:  IM    
Dept. of Internal Medicine, Chung Shan Medical University Hospital, No. 110, Sec. 1, Chien Kuo N. Rd, Taichung, 402, Taiwan, ROC.
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MeSH Terms
Aged, 80 and over
Antioxidants / metabolism*
Biological Markers / blood
Carcinoma, Hepatocellular / blood*,  metabolism
Case-Control Studies
Glutathione / blood
Lipid Metabolism
Lipid Peroxidation
Liver Neoplasms / blood*,  metabolism
Middle Aged
Neoplasm Staging
Oxidative Stress*
Peptide Hormones / blood
Vitamin B Complex / blood*
Vitamin B Deficiency / blood*,  metabolism
Reg. No./Substance:
0/Antioxidants; 0/Biological Markers; 0/Ghrelin; 0/Peptide Hormones; 12001-76-2/Vitamin B Complex; 70-18-8/Glutathione

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