| B-type natriuretic peptide testing for detection of heart failure. | |
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MedLine Citation:
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PMID: 12669945 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The incidence of heart failure (HF) is on the increase with the aging population. Heart failure can manifest as either systolic or diastolic dysfunction. Systolic dysfunction causes impaired ventricular contractility with an ejection fraction of less than 45%. In contrast, diastolic dysfunction is evidenced by impaired ventricular relaxation and an ejection fraction greater than 45%. The diagnosis of HF is challenging with patients who present with acute dyspnea and a history of chronic obstructive pulmonary disease or pneumonia. The pathophysiology of HF and the resulting compensatory mechanisms involve a complex neuroendocrine response that includes a release of natriuretic peptides including B-type natriuretic peptides (BNPs). Elevation of BNP is in response to ventricular wall stress and volume overload from HF. BNP promotes natriuresis, diuresis, and vasodilitation and therefore counteracts some of the deleterious effects of the neuroendocrine response in HF Recently, a new laboratory test for BNP has been developed to assist in rapid identification of patients with HF. Research studies have shown that BNP testing assists in differentiating between cardiac and pulmonary causes of acute dyspnea and could be used to evaluate effectiveness of therapy and as a predictor for length of stay and readmission. |
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Authors:
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Lauren Saul; Melanie Shatzer |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Critical care nursing quarterly Volume: 26 ISSN: 0887-9303 ISO Abbreviation: Crit Care Nurs Q Publication Date: 2003 Jan-Mar |
Date Detail:
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Created Date: 2003-04-02 Completed Date: 2003-04-29 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8704517 Medline TA: Crit Care Nurs Q Country: United States |
Other Details:
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Languages: eng Pagination: 35-9 Citation Subset: N |
Affiliation:
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The University of Pittsburgh Medical Center-Shadyside, Pittsburgh, Pa, USA. saullm@msx.upmc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Atrial Natriuretic Factor
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blood*,
secretion Biological Markers Heart Failure / diagnosis*, physiopathology Humans Natriuretic Peptide, Brain Research |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 114471-18-0/Natriuretic Peptide, Brain; 85637-73-6/Atrial Natriuretic Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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