Document Detail

B-type natriuretic peptide is not a marker of ischemia during dobutamine stress echocardiography.
MedLine Citation:
PMID:  17218198     Owner:  NLM     Status:  MEDLINE    
Elevated levels of B-type natriuretic peptide (BNP) have been reported in association with exercise-induced ischemia. Data regarding BNP as a marker of ischemia during dobutamine stress echocardiography (DSE) are not conclusive. This study was designed to evaluate changes in BNP during DSE. A total of 74 patients referred to rule out ischemia by DSE were enrolled in the study. All patients had DSE using standard protocol. Of 74 patients enrolled, 6 were excluded because of nondiagnostic tests. Of the remaining 68 patients, 15 had positive DSE and 53 were negative for ischemia. The BNP levels (mean +/- SD) in the patients without ischemia were 42.5 pg/mL (+/-SD 47.6) at baseline and 41.9 pg/mL (+/-SD 48.9) at peak, and the measurements in the patients with ischemia were 90 pg/mL (+/-SD 171.7) at baseline and 88 pg/mL (+/-SD 149.2) at peak. BNP levels do not change during DSE with or without evidence of ischemia.
Guillermo Salinas; Iyad N Daher; Anthony O Okorodudu; Masood Ahmad
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography     Volume:  20     ISSN:  1097-6795     ISO Abbreviation:  J Am Soc Echocardiogr     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-12     Completed Date:  2007-02-08     Revised Date:  2007-11-02    
Medline Journal Info:
Nlm Unique ID:  8801388     Medline TA:  J Am Soc Echocardiogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  23-6     Citation Subset:  IM    
Division of Cardiology, University of Texas Medical Branch, Galveston, Texas 77555, USA.
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MeSH Terms
Aged, 80 and over
Biological Markers / blood
Case-Control Studies
Coronary Disease / physiopathology,  ultrasonography*
Echocardiography, Stress / adverse effects,  methods*
Logistic Models
Middle Aged
Multivariate Analysis
Myocardial Ischemia / blood*,  etiology
Natriuretic Peptide, Brain / analysis,  blood*
Prospective Studies
Reference Values
Risk Assessment
Sensitivity and Specificity
Statistics, Nonparametric
Reg. No./Substance:
0/Biological Markers; 114471-18-0/Natriuretic Peptide, Brain

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