Document Detail

B-type natriuretic peptide levels in patients with COPD and normal right ventricular function.
MedLine Citation:
PMID:  18563310     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Evidence suggests that elevated plasma levels of B-type natriuretic peptide (BNP) are found in patients with chronic obstructive pulmonary disease (COPD) and right ventricular dysfunction. We examined the effects of exercise on plasma BNP levels in patients with COPD who have normal right ventricular function METHODS: Seventeen patients with a diagnosis of COPD and normal right ventricular function demonstrated by radionuclide ventriculography, and 17 age-and sex-matched healthy subjects underwent a treadmill exercise test. Plasma BNP levels were measured sequentially before, immediately after, and 1 hour after the exercise test RESULTS: The mean plasma BNP+/-standard deviation levels of the COPD and control groups before exercise were 21.3+/-16 pg/ml and 13.4+/-11 pg/ml, respectively (P>0.05). Mean plasma BNP level measured immediately after exercise was 37.9+/-31 pg/ml in the COPD group, reflecting a statistically significant increase when compared with the initial value (P<0.05). The control group did not show any significant change in plasma BNP levels after the exercise test CONCLUSIONS: Exercise induces an increase in plasma BNP levels in patients with COPD who do not have right ventricular dysfunction at rest. Measurement of exercise-induced BNP levels may be a useful alternative to pulmonary artery catheterisation in identifying the patients who are likely to benefit from long-term oxygen therapy.
Gökmen Gemici; Refik Erdim; Aydin Celiker; Sena Tokay; Tunc Ones; Sabahat Inanir; Ahmet Oktay
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Advances in therapy     Volume:  25     ISSN:  0741-238X     ISO Abbreviation:  Adv Ther     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-25     Completed Date:  2009-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8611864     Medline TA:  Adv Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  674-80     Citation Subset:  T    
Namik Kemal University, Department of Cardiology, Tekirdag, Turkey.
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MeSH Terms
Exercise Test
Middle Aged
Natriuretic Peptide, Brain / biosynthesis*
Pulmonary Disease, Chronic Obstructive / metabolism*,  physiopathology
Respiratory Function Tests
Ventricular Function, Right / physiology*
Reg. No./Substance:
114471-18-0/Natriuretic Peptide, Brain

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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