| B-type natriuretic peptide levels in patients with COPD and normal right ventricular function. | |
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MedLine Citation:
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PMID: 18563310 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Evidence suggests that elevated plasma levels of B-type natriuretic peptide (BNP) are found in patients with chronic obstructive pulmonary disease (COPD) and right ventricular dysfunction. We examined the effects of exercise on plasma BNP levels in patients with COPD who have normal right ventricular function METHODS: Seventeen patients with a diagnosis of COPD and normal right ventricular function demonstrated by radionuclide ventriculography, and 17 age-and sex-matched healthy subjects underwent a treadmill exercise test. Plasma BNP levels were measured sequentially before, immediately after, and 1 hour after the exercise test RESULTS: The mean plasma BNP+/-standard deviation levels of the COPD and control groups before exercise were 21.3+/-16 pg/ml and 13.4+/-11 pg/ml, respectively (P>0.05). Mean plasma BNP level measured immediately after exercise was 37.9+/-31 pg/ml in the COPD group, reflecting a statistically significant increase when compared with the initial value (P<0.05). The control group did not show any significant change in plasma BNP levels after the exercise test CONCLUSIONS: Exercise induces an increase in plasma BNP levels in patients with COPD who do not have right ventricular dysfunction at rest. Measurement of exercise-induced BNP levels may be a useful alternative to pulmonary artery catheterisation in identifying the patients who are likely to benefit from long-term oxygen therapy. |
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Authors:
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Gökmen Gemici; Refik Erdim; Aydin Celiker; Sena Tokay; Tunc Ones; Sabahat Inanir; Ahmet Oktay |
Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Advances in therapy Volume: 25 ISSN: 0741-238X ISO Abbreviation: Adv Ther Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-07-25 Completed Date: 2009-01-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8611864 Medline TA: Adv Ther Country: United States |
Other Details:
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Languages: eng Pagination: 674-80 Citation Subset: T |
Affiliation:
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Namik Kemal University, Department of Cardiology, Tekirdag, Turkey. kardiyolog@ttmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Exercise Test Female Humans Male Middle Aged Natriuretic Peptide, Brain / biosynthesis* Pulmonary Disease, Chronic Obstructive / metabolism*, physiopathology Respiratory Function Tests Ventricular Function, Right / physiology* |
| Chemical | |
Reg. No./Substance:
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114471-18-0/Natriuretic Peptide, Brain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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