Document Detail

B-type natriuretic peptide and its clinical implications in heart failure.
MedLine Citation:
PMID:  15604836     Owner:  NLM     Status:  MEDLINE    
B-type natriuretic peptide (BNP) is a cardiac neurohormone released as preproBNP and then enzymatically cleaved to N-terminal-proBNP and BNP upon ventricular myocyte stretch. Blood measurements of BNP have been used to identify patients with heart failure. Currently, BNP assay is used as a diagnostic and prognostic aid in congestive heart failure. In general, a BNP level <100 pg/mL excludes acutely decompensated heart failure. This article sorts out the literature concerning the practical use of BNP in a variety of clinical scenarios.
Peter A McCullough
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The American heart hospital journal     Volume:  2     ISSN:  1541-9215     ISO Abbreviation:  Am Heart Hosp J     Publication Date:  2004  
Date Detail:
Created Date:  2004-12-17     Completed Date:  2005-02-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101156064     Medline TA:  Am Heart Hosp J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  26-33     Citation Subset:  IM    
Department of Medicine, Division of Cardiology, William Beaumont Hospital, 4949 Coolidge, Royal Oak, MI 48073-1026, USA.
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MeSH Terms
Acute Disease
Age Factors
Ambulatory Care
Body Weight
Decision Trees
Drug Monitoring / methods,  standards
Dyspnea / etiology
Heart Failure / complications,  diagnosis*,  drug therapy,  metabolism*,  mortality
Metabolic Clearance Rate
Middle Aged
Natriuretic Peptide, Brain / metabolism*
Practice Guidelines as Topic
Reference Values
Sensitivity and Specificity
Severity of Illness Index
Sex Characteristics
Treatment Outcome
Reg. No./Substance:
114471-18-0/Natriuretic Peptide, Brain

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