| B-type natriuretic peptide in patients with systemic right ventricle. | |
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MedLine Citation:
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PMID: 17934262 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To examine the diagnostic value of B-type natriuretic peptide (BNP) in patients with systemic right ventricle. METHODS: Plasma BNP levels were measured in 48 outpatients with D-transposition of the great arteries after atrial switch procedure or congenitally corrected transposition of the great arteries. RESULTS: Plasma BNP was < or =20 pg/ml in 52% and <200 pg/ml in all patients, significantly higher in females compared to males (p = 0.004), and positively correlated with age (r = 0.3, p = 0.04). New York Heart Association class I patients had significantly lower BNP than class II patients (p = 0.03). A positive correlation was found between BNP and severity of tricuspid regurgitation (r = 0.5, p < 0.001). Plasma BNP was weakly, negatively correlated to maximum exercise capability, peak oxygen uptake, maximum heart rate during exercise testing and minimal heart rate in the 24-hour Holter monitoring. Additionally, BNP was negatively correlated with flow velocity across the pulmonary valve in patients with congenitally corrected transposition of the great arteries (r = -0.81, p = 0.03). CONCLUSION: Plasma BNP is normal in patients with systemic right ventricle, but increases with deterioration of clinical status and decreasing exercise capability. BNP is positively correlated with severity of tricuspid regurgitation, a prognostic factor for survival. |
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Authors:
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Andreas M E Koch; Stefan Zink; Helmut Singer |
Publication Detail:
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Type: Journal Article Date: 2007-10-10 |
Journal Detail:
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Title: Cardiology Volume: 110 ISSN: 1421-9751 ISO Abbreviation: Cardiology Publication Date: 2008 |
Date Detail:
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Created Date: 2008-04-02 Completed Date: 2008-04-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1266406 Medline TA: Cardiology Country: Switzerland |
Other Details:
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Languages: eng Pagination: 1-7 Citation Subset: IM |
Affiliation:
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Paediatric Cardiology, Department of Paediatrics and Adolescent Medicine, University of Erlangen-Nurnberg, Erlangen, Germany. Andreas.Koch@kinder.imed.uni-erlangen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Biological Markers / blood Child Cohort Studies Disease Progression Echocardiography, Transesophageal Electrocardiography, Ambulatory Exercise Tolerance / physiology Female Heart Defects, Congenital / blood*, diagnosis*, mortality, surgery Heart Function Tests Heart Ventricles / abnormalities* Humans Male Natriuretic Peptide, Brain / analysis, blood* Probability Retrospective Studies Sensitivity and Specificity Survival Rate Ventricular Dysfunction, Right / blood*, congenital*, diagnosis |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 114471-18-0/Natriuretic Peptide, Brain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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