Document Detail

B-type natriuretic peptide in patients with systemic right ventricle.
MedLine Citation:
PMID:  17934262     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine the diagnostic value of B-type natriuretic peptide (BNP) in patients with systemic right ventricle. METHODS: Plasma BNP levels were measured in 48 outpatients with D-transposition of the great arteries after atrial switch procedure or congenitally corrected transposition of the great arteries. RESULTS: Plasma BNP was < or =20 pg/ml in 52% and <200 pg/ml in all patients, significantly higher in females compared to males (p = 0.004), and positively correlated with age (r = 0.3, p = 0.04). New York Heart Association class I patients had significantly lower BNP than class II patients (p = 0.03). A positive correlation was found between BNP and severity of tricuspid regurgitation (r = 0.5, p < 0.001). Plasma BNP was weakly, negatively correlated to maximum exercise capability, peak oxygen uptake, maximum heart rate during exercise testing and minimal heart rate in the 24-hour Holter monitoring. Additionally, BNP was negatively correlated with flow velocity across the pulmonary valve in patients with congenitally corrected transposition of the great arteries (r = -0.81, p = 0.03). CONCLUSION: Plasma BNP is normal in patients with systemic right ventricle, but increases with deterioration of clinical status and decreasing exercise capability. BNP is positively correlated with severity of tricuspid regurgitation, a prognostic factor for survival.
Andreas M E Koch; Stefan Zink; Helmut Singer
Publication Detail:
Type:  Journal Article     Date:  2007-10-10
Journal Detail:
Title:  Cardiology     Volume:  110     ISSN:  1421-9751     ISO Abbreviation:  Cardiology     Publication Date:  2008  
Date Detail:
Created Date:  2008-04-02     Completed Date:  2008-04-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1266406     Medline TA:  Cardiology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  IM    
Paediatric Cardiology, Department of Paediatrics and Adolescent Medicine, University of Erlangen-Nurnberg, Erlangen, Germany.
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MeSH Terms
Biological Markers / blood
Cohort Studies
Disease Progression
Echocardiography, Transesophageal
Electrocardiography, Ambulatory
Exercise Tolerance / physiology
Heart Defects, Congenital / blood*,  diagnosis*,  mortality,  surgery
Heart Function Tests
Heart Ventricles / abnormalities*
Natriuretic Peptide, Brain / analysis,  blood*
Retrospective Studies
Sensitivity and Specificity
Survival Rate
Ventricular Dysfunction, Right / blood*,  congenital*,  diagnosis
Reg. No./Substance:
0/Biological Markers; 114471-18-0/Natriuretic Peptide, Brain

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