Document Detail

B-type natriuretic peptide in ischemic heart disease.
MedLine Citation:
PMID:  12801444     Owner:  NLM     Status:  MEDLINE    
B-type natriuretic peptide (BNP) and the N-terminal fragment of its prohormone (N-proBNP) are released from the heart in response to increased wall stress. Assays for these peptides are now commercially available, and measurement of BNP and N-proBNP is becoming commonplace in patients with suspected heart failure. BNP and N-proBNP facilitate diagnosis and risk stratification in patients with heart failure, and may help guide response to therapy. This review focuses on the emerging role of BNP and N-proBNP measurement in patients with acute coronary syndromes (ACS). Although experimental studies demonstrate rapid BNP release in response to cardiac ischemia, it is unlikely that BNP will be used to diagnose cardiac ischemia, because many other conditions are also associated with modest BNP elevation. In contrast, BNP holds tremendous promise as a prognostic marker in patients with ACS. Studies to date have shown consistently that higher BNP levels are associated with worse clinical outcomes, and that BNP provides unique information to clinical variables, other biomarkers, and left ventricular ejection fraction. Future studies are needed to identify the therapeutic implications of BNP elevation in patients with ACS.
Rajat Deo; James A de Lemos
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current cardiology reports     Volume:  5     ISSN:  1523-3782     ISO Abbreviation:  Curr Cardiol Rep     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-06-12     Completed Date:  2003-12-05     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  100888969     Medline TA:  Curr Cardiol Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  271-7     Citation Subset:  IM    
Division of Cardiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, HA 9.133, Dallas, TX 75390-9047, USA.
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MeSH Terms
Acute Disease
Angina, Unstable / blood*,  etiology,  therapy
Atrial Natriuretic Factor / blood
Cardiotonic Agents / blood*
Myocardial Infarction / blood*,  etiology,  therapy
Myocardial Ischemia / blood*,  complications,  therapy
Natriuretic Peptide, Brain / blood*
Protein Precursors / blood
Reg. No./Substance:
0/Cardiotonic Agents; 0/N-terminal proatrial natriuretic peptide; 0/Protein Precursors; 114471-18-0/Natriuretic Peptide, Brain; 85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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