| B-type natriuretic peptide: a diagnostic, prognostic, and therapeutic tool in heart failure. | |
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MedLine Citation:
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PMID: 14735647 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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B-type natriuretic peptide is a neurohormone secreted from the cardiac ventricles in response to ventricular stretch and pressure overload. It counteracts the vasoconstriction that occurs as a compensatory mechanism in heart failure. A new test for measuring plasma levels of B-type natriuretic peptide can help in the diagnosis and treatment of patients with congestive heart failure. Dyspnea associated with cardiac dysfunction is highly unlikely in patients with levels of the peptide less than 100 pg/mL. Whereas most patients with significant congestive heart failure have levels of the peptide greater than 400 pg/mL, in patients with levels of 100 to 400 pg/mL, left ventricular dysfunction without volume overload, pulmonary embolism, and cor pulmonale must be ruled out. Thus, incorporating measurement of B-type natriuretic peptide into clinical evaluation helps physicians and nurses diagnose heart failure more quickly, especially in patients who have multiple comorbid conditions. Elevated levels of B-type natriuretic peptide indicate a poor prognosis in terms of a higher mortality and more hospital readmissions. Levels of B-type natriuretic peptide could be used to guide therapy and discharge planning for patients admitted with decompensated heart failure. |
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Authors:
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Annu Prahash; Trenda Lynch |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: American journal of critical care : an official publication, American Association of Critical-Care Nurses Volume: 13 ISSN: 1062-3264 ISO Abbreviation: Am. J. Crit. Care Publication Date: 2004 Jan |
Date Detail:
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Created Date: 2004-01-22 Completed Date: 2004-04-13 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9211547 Medline TA: Am J Crit Care Country: United States |
Other Details:
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Languages: eng Pagination: 46-53; quiz 54-5 Citation Subset: IM; N |
Affiliation:
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Winters Center for Heart Failure Research, Baylor College of Medicine, Veterans Affairs Medical Center, Houston, Tex., USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Dyspnea
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diagnosis,
etiology* Female Heart Failure* / complications, diagnosis, drug therapy Humans Male Natriuretic Peptide, Brain* / blood, physiology, therapeutic use Prognosis Radioimmunoassay |
| Chemical | |
Reg. No./Substance:
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114471-18-0/Natriuretic Peptide, Brain |
| Comments/Corrections | |
Erratum In:
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Am J Crit Care. 2004 Mar;13(2):101 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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