Document Detail


B-type natriuretic peptide after open-water and hyperbaric chamber exposure to 10 msw.
MedLine Citation:
PMID:  19653574     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Hyperbaric environment exposure in humans has cardiovascular effects mainly characterized by an increase in afterload and a decrease in cardiac output. In a previous study we did not find B-type natriuretic peptide (BNP) changes in healthy volunteers exposed to hyperbaric oxygen while other authors documented a significant increase in N-terminal pro-BNP after scuba diving. On the basis of these data we hypothesized that dry hyperbaric exposure and scuba diving could have different effects on BNP secretion. METHODS: Nine healthy volunteers performed a 1-h open-sea air dive at 10 m depth (T); a few days later they were compressed in air in a hyperbaric chamber (CT) using the same dive profile. Three venous blood samples were drawn for each session: before starting the dives (T0 and CT0), immediately after exiting the water and the chamber (T1 and CT1), and 5 h later (T2 and CT2). RESULTS: A significant increase in plasma BNP was found with respect to baseline conditions after scuba diving both at T1 (median increment +32.69% [interquartile range +25.62 to +65.35%]) and at T2 (+28.03% [+23.08 to +38.92%]) while no differences were documented after the same dive in dry conditions either at CT1 (+1.34% [-17.57 to +33.55%]) or at CT2 (0.00% [17,67 to +21.62%]). DISCUSSION: These preliminary findings show that scuba diving and dry hyperbaric exposure, although at the same environmental pressure, cause different effects on ventricular loads in healthy subjects.
Authors:
Paolo Grassi; Elisabetta Stenner; Adriano Rinaldi; Giorgio Delbello; Clara Piccinini; Andrea Bussani; Bruno Biancardi; Bruno Biasioli; Giorgio Berlot
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Aviation, space, and environmental medicine     Volume:  80     ISSN:  0095-6562     ISO Abbreviation:  Aviat Space Environ Med     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-05     Completed Date:  2009-09-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7501714     Medline TA:  Aviat Space Environ Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  716-9     Citation Subset:  IM; S    
Affiliation:
Department of Anesthesia and Intensive Care, Azienda Ospedaliero-Universitaria, University of Trieste School of Medicine, Trieste, Italy. paolo.grassi@aots.sanita.fvg.it
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MeSH Terms
Descriptor/Qualifier:
Adult
Diving / physiology*
Humans
Hyperbaric Oxygenation*
Male
Middle Aged
Natriuretic Peptide, Brain / blood*
Chemical
Reg. No./Substance:
114471-18-0/Natriuretic Peptide, Brain

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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