| B-type natriuretic peptide and N-terminal pro-BNP in the acute phase of Kawasaki disease. | |
| | |
MedLine Citation:
|
PMID: 23335186 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: This study was undertaken to identify factors correlating with plasma levels of B-type natriuretic peptide (BNP) and its N-terminal portion (NTpro BNP) in the acute phase of Kawasaki disease (KD). METHODS: This study included 91 patients with KD treated at a hospital affiliated to Hamamatsu University School of Medicine between October 2003 and June 2011. We quantified BNP and NT-pro BNP in the acute phase. The BNP level was expressed as the NT-pro BNP level using the formula NT-pro BNP=9.080×BNP0.923. We sought relationships between NT-pro BNP values and different clinical and laboratory data in the acute phase of KD. RESULTS: Of the 91 patients, 14 failed to respond to the initial intravenous immunoglobulins therapy. NTpro BNP levels were significantly higher in these nonresponders than in the responders (1689.3±1168.8 pg/dL vs. 844.4±1276.3 pg/dL, P<0.001). Seventeen patients developed coronary artery lesions, but this was not associated with NT-proBNP levels. NT-pro BNP was positively correlated with CRP (r=0.421, P<0.001) and negatively correlated with the hematocrit (r=-0.206, P=0.050), Na value (r=-0.214, P=0.041) and albumin level (r=-0.345, P<0.001). Stepwise multiple linear regression analysis with NT-pro BNP as a dependent variable revealed significant correlations with CRP and albumin (beta=0.345, P=0.001; beta=-0.225, P=0.027). CONCLUSIONS: A high level of NT-pro BNP in acute phase KD is associated with systemic inflammatory responses and increased vascular permeability. The NTpro BNP level is a useful marker to identify potential non-responders to IVIG among KD patients. |
| | |
Authors:
|
Satoru Iwashima; Takamichi Ishikawa |
Related Documents
:
|
9562326 - Elevated serum levels of soluble e- and l-selectin in patients with human t-cell lympho... 20440226 - Paraneoplastic granulocytosis in metastatic melanoma. 11866736 - Granulocyte colony-stimulating factor (g-csf) and interleukin (il)-8 in sera from patie... 1950466 - Paraclinical tests in acute-onset optic neuritis: basal data and results of a short fol... 23100526 - Switching therapy from natalizumab to fingolimod in relapsing-remitting multiple sclero... 15074396 - Analysis of factors contributing to higher erythropoietin levels in patients with chron... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2013-1-18 |
Journal Detail:
|
Title: World journal of pediatrics : WJP Volume: - ISSN: 1867-0687 ISO Abbreviation: World J Pediatr Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2013-1-21 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101278599 Medline TA: World J Pediatr Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Pediatrics, Hamamatsu University School of Medicine, Hamamatsu, Japan, iwashima@hama-med.ac.jp. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Successful rescue of a child with fall-related multi-organ injuries.
Next Document: Simultaneous determination of monoamines in rat brain with Pt/MWCNTs@Pdop hybrid nanocomposite using...