Document Detail

B-type Natriuretic Peptides for the Prediction of Cardiovascular Events in Patients With Stable Coronary Heart Disease: The Heart and Soul Study.
MedLine Citation:
PMID:  25053234     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: Brain-type natriuretic peptide (BNP) and the amino-terminal fragment of its prohormone (NT-proBNP) are known predictors of cardiovascular outcomes in patients with coronary heart disease; however, the relative prognostic value of these 2 biomarkers for secondary events remains unclear.
METHODS AND RESULTS: In 983 participants with stable coronary heart disease, we evaluated the association of BNP and NT-proBNP with time to hospitalization for heart failure, nonfatal myocardial infarction, stroke or transient ischemic attack, cardiovascular death, and combined major adverse cardiovascular events (MACE). During an average follow-up of 6.5±3.3 years, both BNP and NT-proBNP were associated with increased risk of MACE in a multivariable-adjusted model (hazard ratio per standard deviation of log BNP: 1.58; 95% CI: 1.32 to 1.89; hazard ratio per standard deviation of log NT-proBNP: 1.84; 95% CI: 1.52 to 2.24). When added to traditional risk factors, NT-proBNP predicted MACE better than BNP (C statistic: 0.76 versus 0.72, P<0.001). Similarly, the addition of NT-proBNP resulted in a greater net reclassification improvement for predicting MACE than the addition of BNP (65% for NT-proBNP, 56% for BNP).
CONCLUSIONS: Both BNP and NT-proBNP were significant predictors of MACE in stable coronary heart disease; however, NT-proBNP was superior to BNP for net risk reclassification for MACE.
Rakesh K Mishra; Alexis L Beatty; Rajesh Jaganath; Mathilda Regan; Alan H B Wu; Mary A Whooley
Related Documents :
8419004 - Accuracy of exercise 201tl myocardial scintigraphy in asymptomatic young men.
11326004 - Chlamydia pneumoniae serology: importance of methodology in patients with coronary hear...
12151864 - High-sensitivity c-reactive protein and cardiovascular risk in patients with coronary h...
7575054 - Perioperative mortality of elective abdominal aortic aneurysm surgery. a clinical predi...
9428844 - Perioperative ventricular dysrhythmias in patients with structural heart disease underg...
20686414 - Cardiovascular magnetic resonance of acute myocardial infarction following traumatic co...
Publication Detail:
Type:  Journal Article     Date:  2014-07-22
Journal Detail:
Title:  Journal of the American Heart Association     Volume:  3     ISSN:  2047-9980     ISO Abbreviation:  J Am Heart Assoc     Publication Date:  2014  
Date Detail:
Created Date:  2014-07-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101580524     Medline TA:  J Am Heart Assoc     Country:  England    
Other Details:
Languages:  eng     Pagination:  -     Citation Subset:  IM    
Copyright Information:
© 2014 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Experimental proof of concept of nanoparticle assisted STED.
Next Document:  Pharmacokinetics and toxicology of a fibroblast activation protein (FAP)-activated prodrug in murine...