| B-type Natriuretic Peptide (BNP) is useful in detecting asymptomatic left ventricular dysfunction in low-income, uninsured patients. | |
| | |
MedLine Citation:
|
PMID: 19934109 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Low-income, uninsured individuals with multiple cardiovascular risk factors (CRFs) are at risk of heart failure (HF). B-type natriuretic peptide (BNP) screening for asymptomatic left ventricular dysfunction (ALVD) has not been tested specifically in this group. The purposes of this study were to describe BNP levels in asymptomatic low-income, uninsured individuals with multiple CRFs and determine the correlation between BNP levels and echocardiography for identifying ALVD. METHODS: This correlational study included 53 patients (age 55 + or - 10 years, 83% non-White, 64% female). BNP testing and echocardiogram (ECHO) were performed. RESULTS: Of the 30 patients (57%) diagnosed with ALVD by ECHO, 21 (40%) had diastolic and 9 (17%) systolic dysfunction. BNP levels were lower among those with normal left ventricular (LV) function (29.6 + or - 24 pg/mL) than those with diastolic (80.2 + or - 69 pg/mL, p = .01) and systolic dysfunction (337.1 + or - 374 pg/mL, p = .009). sParticipants with BNP > or = 50 pg/ mL were 5.75 times more likely to exhibit diastolic dysfunction (odds ratio [OR] = 5.75, 95% confidence interval [CI] 1.29- 25.51; p < .01) and those with BNP > or = 100 pg/mL were 7.80 times more likely to have systolic dysfunction (OR = 7.8, 95% CI 1.60-37.14; p < .005) than those with lower levels. With BNP cut point of 50 pg/mL, area under the curve (AUC) was 0.82 (95% CI 0.63-1.00) with sensitivity of 88% and specificity of 67%. CONCLUSION: BNP is a low-cost method to detect ALVD in high-risk, uninsured, low-income individuals. Elevated BNP levels should prompt initiation of further diagnostic testing and early treatment. |
| | |
Authors:
|
Aurelia Macabasco-O'Connell; Sheba Meymandi; Robert Bryg |
Related Documents
:
|
16355919 - Bnp as a biomarker in heart disease. 17617749 - The combination of b-type natriuretic peptide and c-reactive protein provides increment... 16720429 - Nt-probnp serum levels reflect severity and extent of ischemia in patients admitted wit... 10973769 - Growth hormone and insulin-like growth factor-1 in acute myocardial infarction. 20802129 - Protease corin expression and activity in failing hearts. 14667259 - Cardiac troponin levels in heart failure. 22336189 - Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarc... 3552359 - Hemodynamic effects of orally administered sunitang in humans. 17250879 - Modulation of the risk of coronary sclerosis/myocardial infarction by the interaction b... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-11-23 |
Journal Detail:
|
Title: Biological research for nursing Volume: 11 ISSN: 1552-4175 ISO Abbreviation: Biol Res Nurs Publication Date: 2010 Jan |
Date Detail:
|
Created Date: 2009-12-23 Completed Date: 2010-03-25 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9815758 Medline TA: Biol Res Nurs Country: United States |
Other Details:
|
Languages: eng Pagination: 280-7 Citation Subset: IM; N |
Affiliation:
|
University of California Los Angeles, School of Nursing, Acute Care Section, 700 Tiverton Ave., 4-242 Factor Building, Los Angeles, CA 90095, USA. aoconnel@sonnet.ucla.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Electrocardiography Feasibility Studies Female Humans Male Medically Uninsured* Natriuretic Peptide, Brain / blood* Poverty* Ventricular Dysfunction, Left / diagnosis*, physiopathology |
| Chemical | |
Reg. No./Substance:
|
114471-18-0/Natriuretic Peptide, Brain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Inflammation in Aging Part 2: Implications for the Health of Older People and Recommendations for Nu...
Next Document: A longitudinal description of heart rate variability in 28--34-week-old preterm infants.