Document Detail


B-lineage transcription factors and cooperating gene lesions required for leukemia development.
MedLine Citation:
PMID:  23047478     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Differentiation of hematopoietic stem cells into B-lymphocytes requires the concerted action of specific transcription factors, such as RUNX1, IKZF1, E2A, EBF1 and PAX5. As key determinants of normal B-cell development, B-lineage transcription factors are frequently deregulated in hematological malignancies, such as B-cell precursor acute lymphoblastic leukemia (BCP-ALL), and affected by either chromosomal translocations, gene deletions or point mutations. However, genetic aberrations in this developmental pathway are generally insufficient to induce BCP-ALL, and often complemented by genetic defects in cytokine receptors and tyrosine kinases (IL-7Rα, CRLF2, JAK2, c-ABL1), transcriptional co-factors (TBL1XR1, CBP, BTG1), as well as regulatory pathways that mediate cell cycle control (pRB, INK4A/B). Here, we provide a detailed overview of the genetic pathways that interact with these B-lineage specification factors, and describe how mutations affecting these master regulators together with cooperating lesions drive leukemia development.Leukemia accepted article preview online, 10 October 2012; doi:10.1038/leu.2012.293.
Authors:
E Tijchon; J Havinga; F N van Leeuwen; B Scheijen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-10
Journal Detail:
Title:  Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K     Volume:  -     ISSN:  1476-5551     ISO Abbreviation:  Leukemia     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8704895     Medline TA:  Leukemia     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Laboratory of Pediatric Oncology, Radboud University Medical Centre, Radboud University Centre of Oncology and Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands.
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