Document Detail


B effector cells in rheumatoid arthritis and experimental arthritis.
MedLine Citation:
PMID:  22432771     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rheumatoid arthritis is a chronic autoimmune immune disease affecting approximately 1% of the population. There has been a renewed interest in the role of B cells in rheumatoid arthritis based on the evidence that B cell depletion therapy is effective in the treatment of disease. This review summarizes the current knowledge of the mechanisms by which B cells contribute to autoimmune arthritis including roles as autoantibody producing cells, antigen-presenting cells, cytokine producing cells, and regulatory cells.
Authors:
Alison Finnegan; Susan Ashaye; Keith M Hamel
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-04-19
Journal Detail:
Title:  Autoimmunity     Volume:  45     ISSN:  1607-842X     ISO Abbreviation:  Autoimmunity     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-06-29     Completed Date:  2012-11-07     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  8900070     Medline TA:  Autoimmunity     Country:  England    
Other Details:
Languages:  eng     Pagination:  353-63     Citation Subset:  IM    
Affiliation:
Department of Medicine, Section of Rheumatology, Rush University Medical Center, Chicago, Illinois 60612, USA. Alison_Finnegan@rush.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigen-Presenting Cells / immunology,  metabolism
Arthritis, Experimental / immunology*,  metabolism
Arthritis, Rheumatoid / immunology*,  metabolism
Autoantibodies / immunology
Autoimmune Diseases / immunology,  metabolism
Autoimmunity
B-Lymphocyte Subsets / immunology*,  metabolism
Cytokines / biosynthesis
Humans
Immune Tolerance
Grant Support
ID/Acronym/Agency:
NIHT32HL007605/HL/NHLBI NIH HHS; R01 AR047657/AR/NIAMS NIH HHS; R01AR04657/AR/NIAMS NIH HHS; R01AR056999/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/Cytokines
Comments/Corrections

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