Document Detail


B cells in renal transplantation: pathological aspects and therapeutic interventions.
MedLine Citation:
PMID:  21139038     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
B cells are vital in renal transplantation. B2 cells are part of the adaptive immune system. Activated B cells mature into plasma cells or memory B cells: their life spans can be prolonged by niches. B cells have a wide variety of functions: antibody production, antigen presentation, cytokine production and shaping of the splenic architecture. These functions play a vital role in graft rejection, both T cell-mediated rejection and antibody-mediated rejection. Markers of B cell activity include intragraft B cell infiltration, C4d deposition and circulating donor-specific antibodies. Many therapeutic options target B cells or plasma cells. As greater understanding is gained of their appropriate use, and new agents are developed, we should see prolonged graft survival and reduced graft rejection.
Authors:
Nicholas Barnett; Anthony Dorling; Nizam Mamode
Related Documents :
12791678 - Superoxide-dependent iron uptake: a new role for anion exchange protein 2.
1087558 - Comparison of amphibian whole-cell and cell-free activity towards different transferrins.
16232818 - Iron-oxidizing and leaching activities of sulphur-grown thiobacillus ferrooxidans cells...
17706418 - Adsorption of cu(ii), cd(ii), and pb(ii) from aqueous single metal solutions by cellulo...
6167318 - A mouse neuroblastoma x rat glioma hybrid cell produces immunoreactive substance p-like...
23192708 - Curcumin inhibits telomerase and induces telomere shortening and apoptosis in brain tum...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-12-07
Journal Detail:
Title:  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association     Volume:  26     ISSN:  1460-2385     ISO Abbreviation:  Nephrol. Dial. Transplant.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-23     Completed Date:  2011-09-08     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  8706402     Medline TA:  Nephrol Dial Transplant     Country:  England    
Other Details:
Languages:  eng     Pagination:  767-74     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
B-Lymphocytes / immunology*,  pathology*
Graft Rejection / immunology*,  prevention & control*
Graft Survival / immunology*
Humans
Kidney Transplantation / immunology*
Grant Support
ID/Acronym/Agency:
G0801965//Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Acupuncture effect on thermal tolerance and electrical pain threshold: a randomised controlled trial...
Next Document:  Identification of 20(s)-protopanaxadiol metabolites in human liver microsomes and human hepatocytes.