Document Detail


B cells in renal transplantation: pathological aspects and therapeutic interventions.
MedLine Citation:
PMID:  21139038     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
B cells are vital in renal transplantation. B2 cells are part of the adaptive immune system. Activated B cells mature into plasma cells or memory B cells: their life spans can be prolonged by niches. B cells have a wide variety of functions: antibody production, antigen presentation, cytokine production and shaping of the splenic architecture. These functions play a vital role in graft rejection, both T cell-mediated rejection and antibody-mediated rejection. Markers of B cell activity include intragraft B cell infiltration, C4d deposition and circulating donor-specific antibodies. Many therapeutic options target B cells or plasma cells. As greater understanding is gained of their appropriate use, and new agents are developed, we should see prolonged graft survival and reduced graft rejection.
Authors:
Nicholas Barnett; Anthony Dorling; Nizam Mamode
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-12-07
Journal Detail:
Title:  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association     Volume:  26     ISSN:  1460-2385     ISO Abbreviation:  Nephrol. Dial. Transplant.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-23     Completed Date:  2011-09-08     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  8706402     Medline TA:  Nephrol Dial Transplant     Country:  England    
Other Details:
Languages:  eng     Pagination:  767-74     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
B-Lymphocytes / immunology*,  pathology*
Graft Rejection / immunology*,  prevention & control*
Graft Survival / immunology*
Humans
Kidney Transplantation / immunology*
Grant Support
ID/Acronym/Agency:
G0801965//Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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