Document Detail

B-cell stage and context-dependent requirements for survival signals from BAFF and the B-cell receptor.
MedLine Citation:
PMID:  20727038     Owner:  NLM     Status:  MEDLINE    
One remarkable feature of the immune system is its capacity to maintain constant numbers of resting immune cells despite the complex nature of signals needed throughout development and maturation. For many years, B-cell survival was thought to rely solely on B-cell receptor (BCR) tonic signals that would trigger necessary basal survival pathways. The discovery of the tumor necrosis factor (TNF)-like ligand BAFF(B-cell activating factor belonging to the TNF family)/BLyS (B-lymphocyte stimulator) changed these views entirely, as BAFF-deficient mice lack most mature B cells, and treatment with BAFF inhibitors leads to their loss, establishing BAFF as an unappreciated key B-cell survival factor. BAFF-mediated survival signals have been mapped and signaling crosstalk with the BCR has been identified, explaining the need for both BCR- and BAFF-mediated signals for B-cell survival. However, this crosstalk only explains how BCR and BAFF signals cooperate to produce survival proteins and yet, inactivating pro-apoptotic factors such as FOXO proteins, which may be managed separately by BAFF and the BCR, has emerged as an equally important step for survival. In this review, we present new views on B-cell survival, at all stages of B-cell life, and suggest that, in most cases, survival results from the production of appropriate survival factors balanced with the adequate and timely degradation of pro-apoptotic proteins.
Fabienne Mackay; William A Figgett; Damien Saulep; Melanie Lepage; Margaret L Hibbs
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Immunological reviews     Volume:  237     ISSN:  1600-065X     ISO Abbreviation:  Immunol. Rev.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-23     Completed Date:  2010-12-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7702118     Medline TA:  Immunol Rev     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  205-25     Citation Subset:  IM    
Department of Immunology, Monash University, Melbourne, Australia.
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MeSH Terms
Autoimmunity / immunology
B-Cell Activating Factor / immunology*
B-Lymphocyte Subsets / cytology,  immunology*
B-Lymphocytes / cytology,  immunology*
Neoplasms / immunology
Receptors, Antigen, B-Cell / immunology*
Signal Transduction / immunology*
Reg. No./Substance:
0/B-Cell Activating Factor; 0/Receptors, Antigen, B-Cell

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