| The B cell mass at the clinical onset of type I diabetes. | |
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MedLine Citation:
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PMID: 6385954 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a case of type I diabetes with a duration of 7 days the distribution and volume of the pancreatic endocrine cells were studied using immunocytochemical techniques combined with morphometry. The PP cell rich lobe, making up about 10% of the total pancreatic volume, was not considered in this examination. The volume density and the absolute volume of the B cells was found to be reduced to about one third to one seventh of the values determined in three controls of a similar age and pancreatic volume. The A cell volume was also diminished, whereas the D and PP cell volume remained constant. As B cell necroses could not be detected and insulitis affected only few islets, it was concluded that the destruction of B cells proceeds slowly in type I diabetes and, in the majority of cases, probably starts years before the clinical onset. |
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Authors:
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G Klöppel; C R Drenck; A Carstensen; P U Heitz |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Behring Institute Mitteilungen Volume: - ISSN: 0301-0457 ISO Abbreviation: Behring Inst. Mitt. Publication Date: 1984 Jul |
Date Detail:
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Created Date: 1984-11-16 Completed Date: 1984-11-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0367532 Medline TA: Behring Inst Mitt Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 42-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Child Diabetes Mellitus, Type 1 / metabolism, pathology* Female Histocytochemistry Humans Insulin / metabolism Islets of Langerhans / metabolism, pathology* Male Time Factors |
| Chemical | |
Reg. No./Substance:
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11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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