Document Detail


B cell immunosenescence: different features of naive and memory B cells in elderly.
MedLine Citation:
PMID:  21879287     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Elderly people show a reduced protection against new infections and a decreased response to vaccines as a consequence of impairment of both cellular and humoral immunity. In this paper we have studied memory/naïve B cells in the elderly, evaluating surface immunoglobulin expression, production of the pro- and anti-inflammatory cytokines, tumor necrosis factor (TNF)-α and interleukin (IL)-10, and presence of somatic hypermutation, focusing on the IgG(+)IgD(-)CD27(-) double negative (DN) B cells that are expanded in the elderly. Our results show that naïve B cells from young donors need a sufficiently strong stimulus to be activated "in vitro", while naïve B cells from old subjects are able to produce IL-10 and TNF-α when stimulated "physiologically" (α-CD40/IL-4), suggesting that these cells might play a role in the control of the immuno-inflammatory environment in the elderly. In addition, in the elderly there is an accumulation of DN B cells with a reduced rate of somatic hypermutation. Thus, DN B lymphocytes may be exhausted cells that are expanded and accumulate as a by-product of persistent stimulation or impaired germinal center formation.
Authors:
Silvio Buffa; Matteo Bulati; Mariavaleria Pellicanò; Deborah K Dunn-Walters; Yu-Chang Wu; Giuseppina Candore; Salvatore Vitello; Calogero Caruso; Giuseppina Colonna-Romano
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-08-31
Journal Detail:
Title:  Biogerontology     Volume:  12     ISSN:  1573-6768     ISO Abbreviation:  Biogerontology     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-17     Completed Date:  2012-01-30     Revised Date:  2013-04-24    
Medline Journal Info:
Nlm Unique ID:  100930043     Medline TA:  Biogerontology     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  473-83     Citation Subset:  IM    
Affiliation:
Immunosenescence Unit, Department of Pathobiology, University of Palermo, Corso Tukory, 211, 90134, Palermo, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
B-Lymphocytes / cytology,  drug effects,  immunology*
Cell Aging / immunology*
Humans
Immunoglobulins / immunology
Immunologic Memory*
Interleukin-10 / biosynthesis
Ionomycin / pharmacology
Lymphocyte Activation
Middle Aged
Tetradecanoylphorbol Acetate / pharmacology
Chemical
Reg. No./Substance:
0/Immunoglobulins; 130068-27-8/Interleukin-10; 16561-29-8/Tetradecanoylphorbol Acetate; 56092-81-0/Ionomycin

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