| B cell elimination in systemic lupus erythematosus. | |
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MedLine Citation:
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PMID: 23280492 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Systemic lupus erythematosus (SLE) is an autoimmune disorder with a worldwide distribution, potentially life-threatening with considerable morbidity. The elimination of pathogenic B cells has emerged as a rational therapeutic option. Many open label studies have reported encouraging results in which clinical and serological remission have invariably been described, often enabling the reduction of steroid and immunosuppressive treatment. However, the results from randomized controlled studies have been disappointing and several questions remain to be answered. In this review we will focus on results of B cell direct depletion in the treatment of patients with systemic lupus erythematosus. |
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Authors:
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João Furtado; David A Isenberg |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-27 |
Journal Detail:
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Title: Clinical immunology (Orlando, Fla.) Volume: 146 ISSN: 1521-7035 ISO Abbreviation: Clin. Immunol. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2013-1-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883537 Medline TA: Clin Immunol Country: - |
Other Details:
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Languages: ENG Pagination: 90-103 Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Internal Medicine, Egas Moniz Hospital, Lisbon, Portugal. Electronic address: joaofurtado2010@gmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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