Document Detail


B cell-directed therapies in type 1 diabetes.
MedLine Citation:
PMID:  21531625     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
B cells play a pathogenic role as antigen-presenting cells and autoantibody secretors in the lead up to T cell-mediated autoimmune destruction of insulin-producing β cells in type 1 diabetes (T1D). This has led to significant interest in the use of B cell depletion therapies as a treatment for T1D. In this review, we compare results from five recent studies that used distinct B cell-depleting agents and protocols to successfully prevent and even reverse T1D in the non-obese diabetic (NOD) mouse model. We discuss how information gained from animal studies could be used to improve on the positive outcomes of a completed phase II clinical trial of the B cell-depleting drug rituximab in humans with recent-onset T1D.
Authors:
Eliana Mariño; Pablo A Silveira; Jessica Stolp; Shane T Grey
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-29
Journal Detail:
Title:  Trends in immunology     Volume:  -     ISSN:  1471-4981     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-5-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100966032     Medline TA:  Trends Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Affiliation:
Immunology Program, Garvan Institute of Medical Research, Darlinghurst NSW Australia; St. Vincent's Clinical School, University of New South Wales, Sydney NSW, Australia.
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