Document Detail

B cell-directed therapies in type 1 diabetes.
MedLine Citation:
PMID:  21531625     Owner:  NLM     Status:  Publisher    
B cells play a pathogenic role as antigen-presenting cells and autoantibody secretors in the lead up to T cell-mediated autoimmune destruction of insulin-producing β cells in type 1 diabetes (T1D). This has led to significant interest in the use of B cell depletion therapies as a treatment for T1D. In this review, we compare results from five recent studies that used distinct B cell-depleting agents and protocols to successfully prevent and even reverse T1D in the non-obese diabetic (NOD) mouse model. We discuss how information gained from animal studies could be used to improve on the positive outcomes of a completed phase II clinical trial of the B cell-depleting drug rituximab in humans with recent-onset T1D.
Eliana Mariño; Pablo A Silveira; Jessica Stolp; Shane T Grey
Related Documents :
2472415 - Will heat-stable proteins nonspecifically protect cells from thermal stress?
10598025 - Dimethylarsinic acid exposure causes accumulation of hsp72 in cell nuclei and suppresse...
10943555 - Cold shock response in mammalian cells.
11252355 - Effects of pkc inhibitors on suppression of thermotolerance development in tsaf8 cells.
276875 - Expression of a high molecular weight cell surface glycoprotein (lets protein) by preim...
7911795 - Radiation and taxol effects on synchronized human cervical carcinoma cells.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-29
Journal Detail:
Title:  Trends in immunology     Volume:  -     ISSN:  1471-4981     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-5-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100966032     Medline TA:  Trends Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Immunology Program, Garvan Institute of Medical Research, Darlinghurst NSW Australia; St. Vincent's Clinical School, University of New South Wales, Sydney NSW, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Control of hematopoietic stem cells by the bone marrow stromal niche: the role of reticular cells.
Next Document:  Advances in helminth immunology: optimism for future vaccine design?