Document Detail


B cell depletion reactivates B lymphopoiesis in the BM and rejuvenates the B lineage in aging.
MedLine Citation:
PMID:  21228330     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Aging is associated with a decline in B-lymphopoiesis in the bone marrow and accumulation of long-lived B-cells in the periphery. These changes decrease the body's ability to mount protective antibody responses. We show here that age-related changes in the B lineage are mediated by the accumulating long-lived B cells. Thus, depletion of B-cells in old mice was followed by expansion of multipotent primitive progenitors (MPPs) and common lymphoid progenitors (CLPs), a revival of B-lymphopoiesis in the bone marrow, and generation of a rejuvenated peripheral compartment that enhanced the animal's immune responsiveness to antigenic stimulation. Collectively, our results suggest that immunosenescence in the B-lineage is not irreversible, and that depletion of the long-lived B cells in old mice rejuvenates the B-lineage and enhances immune competence.
Authors:
Zohar Keren; Shulamit Naor; Shahar Nussbaum; Karin Golan; Tomer Itkin; Yoshiteru Sasaki; Marc Schmidt-Supprian; Tsvee Lapidot; Doron Melamed
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-12
Journal Detail:
Title:  Blood     Volume:  -     ISSN:  1528-0020     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Immunology, Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel;
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