| B-cell clonality in the liver of hepatitis C virus-infected patients. | |
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MedLine Citation:
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PMID: 19340908 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: The association of hepatitis C virus (HCV) infection with type II mixed cryoglobulinemia is well established, but the role of HCV in B-cell lymphoma remains controversial. In patients with HCV infection, B-cell clonal expansions have been detected in peripheral blood and bone marrow, and a high prevalence of B-cell non-Hodgkin's lymphomas has been documented. Liver biopsies in chronic HCV infection frequently show portal lymphoid infiltrates with features of B follicles, whose clonality has not yet been investigated. The object of this study was to determine the frequency of liver-infiltrating monoclonal B-cells in 40 patients with HCV infection. METHODS: Eight hundred and forty-eight patients were studied prospectively, including 40 HCV-positive patients and 808 patients with chronic hepatitis B virus (HBV) infection. Immunohistochemical study for B- and T-cell markers was performed on the paraffin-embedded liver tissue sections. The clonality of lymphoid B-cells was tested using a polymerase chain reaction (PCR) approach designed to identify immunoglobulin heavy chain gene (IgH) rearrangements. RESULTS: Liver-infiltrating monoclonal B-cells were detected in the liver for 4 (10%) of 40 HCV-positive patients but were present in only 3 (0.37%) of 808 liver biopsy specimens with chronic HBV infection. Chi-square testing showed that the monoclonal B-cells infiltration in the liver was more frequent in the HCV-infected patients (P = 0.000). A clonal IgH rearrangement was detected in 5 (71.4%) of 7 liver biopsy specimens with monoclonal B-cells infiltration. In 2 of 5 patients with both a clonal B-cell expansion and monoclonal B-cells infiltration in the liver, a definite B-cell malignancy was finally diagnosed. CONCLUSION: Liver-infiltrating monoclonal B-cells are detected in the liver of patients with chronic HCV and HBV infection. A high percentage of patients with monoclonal B-cells infiltration and B-cell clonality in the liver were finally diagnosed as having a definite B-cell malignancy. |
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Authors:
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He-Bin Fan; You-Fu Zhu; An-Shen Chen; Mu-Xiu Zhou; Fu-Ming Yan; Xiao-Ju Ma; Hao Zhou |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: World journal of gastroenterology : WJG Volume: 15 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-04-02 Completed Date: 2009-04-17 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
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Languages: eng Pagination: 1636-40 Citation Subset: IM |
Affiliation:
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Department of Infectious Disease, The People's Liberation Army 161 Hospital, Wuhan, Hubei Province, China. fan_hebin@126.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged B-Lymphocytes / immunology* Hepacivirus / immunology* Hepatitis B / immunology, pathology, virology Hepatitis B virus / immunology Hepatitis C, Chronic / immunology*, pathology, virology* Humans Liver / cytology, immunology*, pathology, virology* Lymphoma, B-Cell* / immunology, virology Male Middle Aged Prospective Studies |
| Comments/Corrections | |
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