Document Detail


B cell clonality in gastric lymphoid tissues of patients with Sjögren's syndrome.
MedLine Citation:
PMID:  8660105     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine the prevalence of mucosa associated lymphoid tissue (MALT) in the stomach and of a possible antigen driven proliferation, in patients with Sjögren's syndrome (SS). METHODS: Twenty one patients with primary SS and 80 dyspeptic controls underwent upper endoscopy. Lymphoid tissue and Helicobacter pylori were assessed by histopathological analysis. Epstein-Barr virus (EBV) or human herpes virus-6 (HHV-6) genome were studied by polymerase chain reaction (PCR) DNA amplification. Two PCR VDJ procedures were used to detect immunoglobulin heavy chain (IgH) gene rearrangement. RESULTS: Organised MALT was found in 33.3% of the patients, compared with 21.5% of the controls (NS). H pylori infection was seen in 71% of patients and 63% of controls. Genomic EBV or HHV-6 was found in a minor portion of SS gastric tissues. B cell expansion was detected in nine of the 21 patients. Infectious agents in the stomach might have contributed to B cell clonality only in 55.5% of the cases. No strict relationship was found between lymphoid follicles and clonality. CONCLUSION: Lymphoid accumulation in the gastric mucosa is common in Sjögren's syndrome, but full evidence for an antigen driven B cell expansion could not be demonstrated. Only a portion of those with clonal B cell expansion had evidence of an infectious agent. Other unknown infectious agents or factors related to the underlying disease (autoantigen) and its tissue environment may have a further role as possible causes of B clonal expansion in the gastric mucosa.
Authors:
G F Ferraccioli; D Sorrentino; S De Vita; L Casatta; A Labombarda; C Avellini; R Dolcetti; D Di Luca; C A Beltrami; M Boiocchi; E Bartoli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of the rheumatic diseases     Volume:  55     ISSN:  0003-4967     ISO Abbreviation:  Ann. Rheum. Dis.     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-07-30     Completed Date:  1996-07-30     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372355     Medline TA:  Ann Rheum Dis     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  311-6     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, School of Medicine, Udine, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
B-Lymphocytes / pathology*
Clone Cells
Gastric Mucosa / immunology,  pathology
Genome, Viral
Helicobacter Infections / immunology,  pathology
Helicobacter pylori
Herpesvirus 4, Human / genetics
Herpesvirus 6, Human / genetics
Humans
Immunity, Cellular
Lymphoid Tissue / immunology,  pathology*
Lymphoma, B-Cell, Marginal Zone / immunology,  pathology*
Middle Aged
Polymerase Chain Reaction
Sjogren's Syndrome / immunology,  microbiology,  pathology*,  virology
Stomach / immunology,  pathology*
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