Document Detail


The B-cell antigen receptor of the five immunoglobulin classes.
MedLine Citation:
PMID:  1881434     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Several proteins associate with surface IgM to form the antigen receptor. We show that just two, the alpha and beta associated chains, are sufficient to reconstitute an IgM surface receptor in fibroblasts. Contrary to expectation, a common alpha chain associates with all five immunoglobulin classes. We propose that B-cell antigen receptors consist of a common alpha/beta heterodimer associated with each immunoglobulin class. But the classes differ both in the glycosylation of their associated alpha chain and in their dependence on alpha/beta for surface transport.
Authors:
A R Venkitaraman; G T Williams; P Dariavach; M S Neuberger
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nature     Volume:  352     ISSN:  0028-0836     ISO Abbreviation:  Nature     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-10-01     Completed Date:  1991-10-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  777-81     Citation Subset:  IM    
Affiliation:
MRC Laboratory of Molecular Biology, Cambridge, UK.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Cell Line
DNA / genetics
Fibroblasts / immunology
Glycosylation
Immunoglobulin A / metabolism
Immunoglobulin D / genetics,  metabolism
Immunoglobulin E / metabolism
Immunoglobulin G / metabolism
Immunoglobulin M / metabolism*
Macromolecular Substances
Mice
Molecular Sequence Data
Plasmacytoma / immunology
Receptors, Antigen, B-Cell / chemistry,  genetics,  immunology*
Transfection
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Immunoglobulin A; 0/Immunoglobulin D; 0/Immunoglobulin G; 0/Immunoglobulin M; 0/Macromolecular Substances; 0/Receptors, Antigen, B-Cell; 37341-29-0/Immunoglobulin E; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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