| B cell activating factor (BAFF) in the natural history of chronic hepatitis C virus liver disease and mixed cryoglobulinaemia. | |
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MedLine Citation:
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PMID: 23039894 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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B cell activating factor (BAFF) plays a crucial role in the process of development, maturation and activation of B lymphocytes. Chronic hepatitis C virus (HCV) infection is characterized by multiple B cell disorders. It is a major cause of type II mixed cryoglobulinaemia (MC). We measured serum BAFF levels in several clinical situations to elucidate the potential role of BAFF in chronic HCV infection. We used a commercially available solid phase enzyme-linked immunosorbent assay. We estimated serum BAFF in stored sera from uninfected controls (n = 8), patients with chronic hepatitis B virus infection HBV (n = 5) and chronic HCV infection with (n = 16) and without mixed cryoglobulinaemia (n = 14). In two patients with HCV and MC we correlated BAFF with HCV RNA after pegylated interferon (peg-I). We correlated serum BAFF levels at baseline and at 12 weeks with treatment response: sustained virological response SVR (n = 5), non-responders (n = 6) and relapsers (n = 2). Finally, we estimated BAFF levels after complete depletion of B cells with rituximab in patients with chronic HCV with MC (n = 3). Serum levels of BAFF were increased in chronic HCV with MC, but not in chronic HBV infection, suggesting an association between BAFF and cryoglobulinaemia. Peg-I increased BAFF levels in serum and this paralleled HCV RNA very closely. Serum BAFF levels at week 12 of therapy with peg-I and R were significantly higher in responders than non-responders. Finally, B cell depletion was associated with markedly increased levels of BAFF. |
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Authors:
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G Lake-Bakaar; I Jacobson; A Talal |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical and experimental immunology Volume: 170 ISSN: 1365-2249 ISO Abbreviation: Clin. Exp. Immunol. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-10-08 Completed Date: 2013-03-18 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 0057202 Medline TA: Clin Exp Immunol Country: England |
Other Details:
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Languages: eng Pagination: 231-7 Citation Subset: IM |
Copyright Information:
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© 2012 The Authors Clinical and Experimental Immunology © 2012 British Society for Immunology. |
Affiliation:
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Center for the Study of Hepatitis C, Weill Medical College Cornell University, New York, NY, USA. glakebak@bidmc.harvard.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Monoclonal, Murine-Derived
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pharmacology B-Cell Activating Factor / blood*, immunology* B-Lymphocytes / drug effects, immunology* Cryoglobulinemia / blood, immunology*, virology Female Hepacivirus / immunology* Hepatitis B / blood, immunology Hepatitis C, Chronic / blood*, immunology* Humans Interferon-alpha / immunology Male Middle Aged Polyethylene Glycols RNA, Viral / immunology Recombinant Proteins / immunology |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal, Murine-Derived; 0/B-Cell Activating Factor; 0/Interferon-alpha; 0/Polyethylene Glycols; 0/RNA, Viral; 0/Recombinant Proteins; 0/TNFSF13B protein, human; 0/peginterferon alfa-2b; 0/rituximab |
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