Document Detail


B cell activating factor (BAFF) in the natural history of chronic hepatitis C virus liver disease and mixed cryoglobulinaemia.
MedLine Citation:
PMID:  23039894     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
B cell activating factor (BAFF) plays a crucial role in the process of development, maturation and activation of B lymphocytes. Chronic hepatitis C virus (HCV) infection is characterized by multiple B cell disorders. It is a major cause of type II mixed cryoglobulinaemia (MC). We measured serum BAFF levels in several clinical situations to elucidate the potential role of BAFF in chronic HCV infection. We used a commercially available solid phase enzyme-linked immunosorbent assay. We estimated serum BAFF in stored sera from uninfected controls (n = 8), patients with chronic hepatitis B virus infection HBV (n = 5) and chronic HCV infection with (n = 16) and without mixed cryoglobulinaemia (n = 14). In two patients with HCV and MC we correlated BAFF with HCV RNA after pegylated interferon (peg-I). We correlated serum BAFF levels at baseline and at 12 weeks with treatment response: sustained virological response SVR (n = 5), non-responders (n = 6) and relapsers (n = 2). Finally, we estimated BAFF levels after complete depletion of B cells with rituximab in patients with chronic HCV with MC (n = 3). Serum levels of BAFF were increased in chronic HCV with MC, but not in chronic HBV infection, suggesting an association between BAFF and cryoglobulinaemia. Peg-I increased BAFF levels in serum and this paralleled HCV RNA very closely. Serum BAFF levels at week 12 of therapy with peg-I and R were significantly higher in responders than non-responders. Finally, B cell depletion was associated with markedly increased levels of BAFF.
Authors:
G Lake-Bakaar; I Jacobson; A Talal
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  170     ISSN:  1365-2249     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-08     Completed Date:  2013-03-18     Revised Date:  2013-11-05    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  231-7     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors Clinical and Experimental Immunology © 2012 British Society for Immunology.
Affiliation:
Center for the Study of Hepatitis C, Weill Medical College Cornell University, New York, NY, USA. glakebak@bidmc.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
Antibodies, Monoclonal, Murine-Derived / pharmacology
B-Cell Activating Factor / blood*,  immunology*
B-Lymphocytes / drug effects,  immunology*
Cryoglobulinemia / blood,  immunology*,  virology
Female
Hepacivirus / immunology*
Hepatitis B / blood,  immunology
Hepatitis C, Chronic / blood*,  immunology*
Humans
Interferon-alpha / immunology
Male
Middle Aged
Polyethylene Glycols
RNA, Viral / immunology
Recombinant Proteins / immunology
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal, Murine-Derived; 0/B-Cell Activating Factor; 0/Interferon-alpha; 0/Polyethylene Glycols; 0/RNA, Viral; 0/Recombinant Proteins; 0/TNFSF13B protein, human; 0/peginterferon alfa-2b; 0/rituximab
Comments/Corrections

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