Document Detail

B cell abnormalities in systemic lupus erythematosus.
MedLine Citation:
PMID:  15180894     Owner:  NLM     Status:  MEDLINE    
Systemic lupus erythematosus (SLE) is a chronic, multisystem autoimmune disease characterized by the differentiation of short- and long-lived immunoglobulin secreting plasma cells that secrete pathogenic autoantibodies. Ectopic germinal centers and plasma cells secreting autoantibodies have been observed in lupus nephritis kidneys. Candidate genetic susceptibility loci for SLE include genes that affect differentiation and survival of plasma cells, such as those that influence activation, proliferation, cytokine and chemokine secretion/responsiveness, and apoptosis of the T and B cells that are involved in humoral immunity generated in germinal centers, as well as genes that are involved in presentation and clearance of apoptotic material and autoantigens by antigen presenting cells and other phagocytes. Emerging data have demonstrated that B lymphocytes are active participants in humoral immune responses that lead to T-dependent and T-independent differentiation of immunoglobulin-secreting plasma cells by homotypic CD154-CD40 interactions as well as continued stimulation by B cell activating factor through B cell maturation antigen, B cell activating factor receptor and transmembrane activater.
Amrie C Grammer; Peter E Lipsky
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Publication Detail:
Type:  Journal Article; Review     Date:  2003-12-02
Journal Detail:
Title:  Arthritis research & therapy     Volume:  5 Suppl 4     ISSN:  1478-6362     ISO Abbreviation:  Arthritis Res. Ther.     Publication Date:  2003  
Date Detail:
Created Date:  2004-06-07     Completed Date:  2005-07-05     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  101154438     Medline TA:  Arthritis Res Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  S22-7     Citation Subset:  IM    
Autoimmunity Branch of the Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA.
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MeSH Terms
Antigens, CD40
B-Cell Activating Factor
B-Cell Activation Factor Receptor
B-Lymphocytes / immunology*
CD40 Ligand
Immunoglobulins / immunology
Lupus Erythematosus, Systemic / immunology*
Membrane Proteins
Receptors, Tumor Necrosis Factor
Tumor Necrosis Factor-alpha
Reg. No./Substance:
0/Antigens, CD40; 0/B-Cell Activating Factor; 0/B-Cell Activation Factor Receptor; 0/Immunoglobulins; 0/Membrane Proteins; 0/Receptors, Tumor Necrosis Factor; 0/TNFRSF13C protein, human; 0/TNFSF13B protein, human; 0/Tumor Necrosis Factor-alpha; 147205-72-9/CD40 Ligand

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