Document Detail


B Vitamins and n-3 Fatty Acids for Brain Development and Function: Review of Human Studies.
MedLine Citation:
PMID:  22678093     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: Nutrition is one of many factors that affect brain development and functioning, and in recent years the role of certain nutrients has been investigated. B vitamins and n-3 polyunsaturated fatty acids (PUFA) are two of the most promising and widely studied nutritional factors. Methods: In this review, we provide an overview of human studies published before August 2011 on how vitamin B(6), folate, vitamin B(12) and n-3 PUFA may affect the brain, their nutrient status and the existing evidence for an association between these nutrients and brain development, brain functioning and depression during different stages of the life cycle. Results: No recommendation can be given regarding a role of B vitamins, either because the number of studies on B vitamins is too limited (pregnant and lactating women and children) or the studies are not consistent (adults and elderly). For n-3 PUFA, observational evidence may be suggestive of a beneficial effect; however, this has not yet been sufficiently replicated in randomized controlled trials (RCTs). Conclusions: We found that the existing evidence from observational studies as well as RCTs is generally too limited and contradictory to draw firm conclusions. More research is needed, particularly a combination of good-quality long-term prospective studies and well-designed RCTs.
Authors:
Ondine van de Rest; Lenneke W A van Hooijdonk; Esmée Doets; Olga J G Schiepers; Ans Eilander; Lisette C P G M de Groot
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-01
Journal Detail:
Title:  Annals of nutrition & metabolism     Volume:  60     ISSN:  1421-9697     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8105511     Medline TA:  Ann Nutr Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  272-292     Citation Subset:  -    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
Affiliation:
Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands.
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