| B-Vitamins, Methylenetetrahydrofolate Reductase (MTHFR) and Hypertension. | |
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MedLine Citation:
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PMID: 22237773 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Hypertension is a leading risk factor for cardiovascular disease (CVD) and stroke. A common polymorphism in the gene encoding the enzyme methylenetetrahydrofolate reductase (MTHFR), previously identified as the main genetic determinant of elevated homocysteine concentration and also recognized as a risk factor for CVD, appears to be independently associated with hypertension. The B-vitamin riboflavin is required as a cofactor by MTHFR and recent evidence suggests it may have a role in modulating blood pressure, specifically in those with the homozygous mutant MTHFR 677 TT genotype. If studies confirm that this genetic predisposition to hypertension is correctable by low-dose riboflavin, the findings could have important implications for the management of hypertension given that the frequency of this polymorphism ranges from 3 to 32 % worldwide. |
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Authors:
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Mary Ward; Carol P Wilson; J J Strain; Geraldine Horigan; John M Scott; Helene McNulty |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition Volume: 81 ISSN: 0300-9831 ISO Abbreviation: Int J Vitam Nutr Res Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2012-01-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1273304 Medline TA: Int J Vitam Nutr Res Country: Switzerland |
Other Details:
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Languages: eng Pagination: 240-4 Citation Subset: IM |
Affiliation:
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Nothern Ireland Centre for Food and Health, University of Ulster, Coleraine BT52 1SA, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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