| B-Myb, a repressed trans-activating protein. | |
MedLine Citation:
|
PMID: 9428611 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
B-Myb belongs to a family of related transcription factors which share a unique DNA binding domain. B-Myb plays an important role in regulation of the cell cycle. Its expression is upregulated by the human papilloma virus HPV16 E7 oncoprotein. Overexpression of B-Myb can bypass p53-mediated cell cycle arrest. The founding member of the myb gene family, c-Myb, and A-Myb are involved in hematopoiesis and neurogenesis, respectively, and are both activators of gene transcription. Whether B-Myb is a transactivator or a repressor, however, has remained a matter of discussion. We reviewed the transactivation potential of B-Myb in yeast, taking advantage of the fact that inducible gene activation is an evolutionarily conserved process. By mutational analysis we localized a conserved activation domain in B-Myb. In vertebrate cells the transactivation potential of B-Myb is concealed by the C-terminal part of the protein. We show that the cell cycle regulators cyclin A and cyclin E activate B-Myb by eradicating the inhibition mediated by its carboxy-terminus. Our data suggest that in vertebrates the trans-activating function of B-Myb is regulated during the cell cycle and link Myb functions to cell cycle progression. |
Authors:
|
S Ansieau; E Kowenz-Leutz; R Dechend; A Leutz |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of molecular medicine (Berlin, Germany) Volume: 75 ISSN: 0946-2716 ISO Abbreviation: J. Mol. Med. Publication Date: 1997 Nov-Dec |
Date Detail:
|
Created Date: 1998-02-09 Completed Date: 1998-02-09 Revised Date: 2011-07-08 |
Medline Journal Info:
|
Nlm Unique ID: 9504370 Medline TA: J Mol Med (Berl) Country: GERMANY |
Other Details:
|
Languages: eng Pagination: 815-9 Citation Subset: IM |
Affiliation:
|
Max Delbrück Center for Molecular Medicine, Berlin, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amino Acid Sequence Animals Cell Cycle / genetics Cell Cycle Proteins* Cell Division / genetics Chickens DNA-Binding Proteins / genetics, physiology* Gene Expression Regulation / drug effects Humans Mice Molecular Sequence Data Sequence Homology, Amino Acid Trans-Activators / genetics, physiology* Transcription Factors / genetics, physiology* Transcriptional Activation Xenopus |
| Chemical | |
Reg. No./Substance:
|
0/Cell Cycle Proteins; 0/DNA-Binding Proteins; 0/MYBL2 protein, human; 0/Mybl2 protein, mouse; 0/Trans-Activators; 0/Transcription Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Tumor cytogenetics revisited: comparative genomic hybridization and spectral karyotyping.
Next Document: Inducible expression of p21WAF-1/CIP-1/SDI-1 from a promoter conversion retroviral vector.