| B Cell Immunity in Allergic Nasal Mucosa Induces T helper 2 Cell Differentiation. | |
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MedLine Citation:
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PMID: 22454245 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: The pathogenesis of allergic diseases is to be further understood. Recent studies indicate that B cells are involved in the immune regulation. The present study aimed to investigate the role of B cells in the initiation of skewed T helper (Th)2 polarization. METHODS: The surgically removed nasal mucosal specimens from 24 patients with allergic rhinitis (AR) and 22 patients with non-AR (nAR) were collected. B cells isolated from the AR nasal mucosa were characterized. The effect of B cells on inducing naïve CD4+ T cells to differentiate into Th2 cells was evaluated with a cell culture model. RESULTS: Abundant B cells were detected in the nasal mucosa of patients with AR, which also expressed high levels of T cell immunoglobulin mucin domain (TIM)4 and costimulatory molecules. High levels of Staphylococcal enterotoxin B (SEB) were detected in the AR nasal mucosa. Expression of TIM4 could be induced in naïve B cells in the presence of SEB in culture. TIM4+ B cells could induce naïve CD4+ T cells to differentiate into Th2 cells. CONCLUSIONS: TIM4+ B cells from AR nasal mucosa can induce skewed Th2 polarization. It may be a potential therapeutic target in the treatment of AR. B cells plays an important role in the initiation of Th2 polarization KEY MESSAGES: • High frequency of B cells exists in nasal mucosa of allergic rhinitis • These B cells express high levels of TIM4 • TIM4+ B cells can initiate the skewed Th2 polarization. |
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Authors:
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Shuqi Qiu; Yun Du; Xiaobei Duan; Xiaorui Geng; Jianxiong Xie; Han Gao; Ping-Chang Yang |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-3-28 |
Journal Detail:
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Title: Journal of clinical immunology Volume: - ISSN: 1573-2592 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-3-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8102137 Medline TA: J Clin Immunol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Shenzhen ENT Institute, Shenzheng, Guangzhou, China, qiuqi66858@163.com. |
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