Document Detail


B cell immunity in allergic nasal mucosa induces T helper 2 cell differentiation.
MedLine Citation:
PMID:  22454245     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The pathogenesis of allergic diseases is to be further understood. Recent studies indicate that B cells are involved in the immune regulation. The present study aimed to investigate the role of B cells in the initiation of skewed T helper (Th)2 polarization.
METHODS: The surgically removed nasal mucosal specimens from 24 patients with allergic rhinitis (AR) and 22 patients with non-AR (nAR) were collected. B cells isolated from the AR nasal mucosa were characterized. The effect of B cells on inducing naïve CD4+ T cells to differentiate into Th2 cells was evaluated with a cell culture model.
RESULTS: Abundant B cells were detected in the nasal mucosa of patients with AR, which also expressed high levels of T cell immunoglobulin mucin domain (TIM)4 and costimulatory molecules. High levels of Staphylococcal enterotoxin B (SEB) were detected in the AR nasal mucosa. Expression of TIM4 could be induced in naïve B cells in the presence of SEB in culture. TIM4+ B cells could induce naïve CD4+ T cells to differentiate into Th2 cells.
CONCLUSIONS: TIM4+ B cells from AR nasal mucosa can induce skewed Th2 polarization. It may be a potential therapeutic target in the treatment of AR. B cells plays an important role in the initiation of Th2 polarization.
KEY MESSAGES: • High frequency of B cells exists in nasal mucosa of allergic rhinitis • These B cells express high levels of TIM4 • TIM4+ B cells can initiate the skewed Th2 polarization.
Authors:
Shuqi Qiu; Yun Du; Xiaobei Duan; Xiaorui Geng; Jianxiong Xie; Han Gao; Ping-Chang Yang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-03-28
Journal Detail:
Title:  Journal of clinical immunology     Volume:  32     ISSN:  1573-2592     ISO Abbreviation:  J. Clin. Immunol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-04     Completed Date:  2013-01-22     Revised Date:  2013-07-15    
Medline Journal Info:
Nlm Unique ID:  8102137     Medline TA:  J Clin Immunol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  886-95     Citation Subset:  IM    
Affiliation:
Shenzhen ENT Institute, Shenzheng, Guangzhou, China. qiuqi66858@163.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Antigens, CD19 / analysis
B-Lymphocytes / immunology*
Cell Differentiation
Cells, Cultured
Enterotoxins / analysis
Female
Humans
Lymphocyte Activation
Male
Membrane Proteins / biosynthesis*,  genetics
Nasal Mucosa / immunology*
RNA Interference
RNA, Small Cytoplasmic
Rhinitis, Allergic, Perennial / immunology*
Th2 Cells / immunology*
Grant Support
ID/Acronym/Agency:
177843//Canadian Institutes of Health Research; 191063//Canadian Institutes of Health Research; 220058//Canadian Institutes of Health Research
Chemical
Reg. No./Substance:
0/Antigens, CD19; 0/Enterotoxins; 0/Membrane Proteins; 0/RNA, Small Cytoplasmic; 0/TIMD4 protein, human; 39424-53-8/enterotoxin B, staphylococcal

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