| Azoospermia and paternal autosomal ring chromosomes: case report and literature review. | |
| | |
MedLine Citation:
|
PMID: 21843971 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Two men of the same family presented with ring chromosome 22 and azoospermia. The literature on all autosomal ring chromosomes and semen abnormalities was reviewed. Autosomal ring chromosomes were often associated with a low sperm count. This is probably as a result of gamete instability at meiosis due to the ring chromosome which leads to an increased breakdown. In addition, ring chromosomes transmitted from the parents may manifest quite differently in the progeny. Prior to treating these patients with assisted reproduction, appropriate counselling should be offered, in view of the varying phenotypic manifestations of ring chromosomes in the resulting progeny, and prenatal diagnosis or preimplantation diagnosis must be considered. Two men of the same family presented with ring chromosome 22 and azoospermia. We reviewed literature on the presence of semen abnormalities in males with ring chromosomes. Autosomal rings chromosomes were often associated with a low sperm count. This is probably due to altered chromosome division due to the ring chromosome at meiosis leading to an increased chromosome breakdown resulting in poor spermatogenesis. In addition, ring chromosomes transmitted from the parents may manifest quite differently in the offspring and at times have more severe characteristics. Prior to treating these patients with assisted reproduction, appropriate counselling should be offered. Prospective parents should be fully aware of the varying manifestations of ring chromosomes in the resulting progeny and should consider embryo biopsy or tests during pregnancy to ensure that the offspring has the right chromosomes. |
| | |
Authors:
|
Hemashree Rajesh; Mary-Louise Freckmann; Michael Chapman |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-5-27 |
Journal Detail:
|
Title: Reproductive biomedicine online Volume: - ISSN: 1472-6491 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-8-16 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101122473 Medline TA: Reprod Biomed Online Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Reproductive Healthcare Ltd. All rights reserved. |
Affiliation:
|
The St. George Hospital, University of New South Wales, Sydney, Australia; Department of Obstetrics and Gynaecology, Block 6, Level 7, Singapore General Hospital, Outram Road, Singapore 169608, Singapore. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: No association between endogenous LH and pregnancy in a GnRH antagonist protocol: part II, recombina...
Next Document: Treatment of status epilepticus with plasmapheresis in a patient with thrombotic thrombocytopenic pu...