| Azole antifungal resistance in Aspergillus fumigatus: 2008 and 2009. | |
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MedLine Citation:
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PMID: 20729241 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Resistance to azole antifungal drugs in Aspergillus fumigatus is now a major clinical problem in some locations. Here we update our previous experience with data from 2008-09. METHODS: We tested all A. fumigatus isolates submitted to the Mycology Reference Centre Manchester in 2008 and 2009 for susceptibility to itraconazole, voriconazole and posaconazole. We undertook CYP51A sequencing for most of the azole-resistant isolates. RESULTS: Of 230 isolates, 64 (28%) were azole resistant. In 2008 and 2009, 14% and 20% of patients had resistant isolates, respectively. During this period 62 of 64 (97%) were itraconazole resistant, 2 of 64 (3%) were only voriconazole resistant and 78% of cases were multi-azole resistant. Forty-three percent of isolates did not carry a cyp51A mutation (previously the most common azole resistance mechanism), indicating that other mechanisms must be responsible and are increasing in frequency. CONCLUSIONS: Azole resistance is evolving and growing in frequency. Established and novel mechanisms may be responsible. |
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Authors:
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Ahmed Bueid; Susan J Howard; Caroline B Moore; Malcolm D Richardson; Elizabeth Harrison; Paul Bowyer; David W Denning |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-20 |
Journal Detail:
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Title: The Journal of antimicrobial chemotherapy Volume: 65 ISSN: 1460-2091 ISO Abbreviation: J. Antimicrob. Chemother. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-20 Completed Date: 2011-01-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7513617 Medline TA: J Antimicrob Chemother Country: England |
Other Details:
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Languages: eng Pagination: 2116-8 Citation Subset: IM |
Affiliation:
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The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antifungal Agents
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pharmacology* Aspergillosis / microbiology* Aspergillus fumigatus / drug effects*, isolation & purification Azoles / pharmacology* Cytochrome P-450 Enzyme System / genetics DNA, Fungal / chemistry, genetics Drug Resistance, Fungal* Fungal Proteins / genetics Humans Itraconazole / pharmacology Microbial Sensitivity Tests Pyrimidines / pharmacology Sequence Analysis, DNA Triazoles / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Antifungal Agents; 0/Azoles; 0/DNA, Fungal; 0/Fungal Proteins; 0/Pyrimidines; 0/Triazoles; 0/posaconazole; 0/voriconazole; 84625-61-6/Itraconazole; 9035-51-2/Cytochrome P-450 Enzyme System; EC 1.14.14.-/cytochrome P-450 CYP51A, Aspergillus |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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