Document Detail

Azilsartan Medoxomil Plus Chlorthalidone Reduces Blood Pressure More Effectively Than Olmesartan Plus Hydrochlorothiazide in Stage 2 Systolic Hypertension.
MedLine Citation:
PMID:  22710649     Owner:  NLM     Status:  Publisher    
Azilsartan medoxomil, an effective, long-acting angiotensin II receptor blocker, is a new treatment for hypertension that is also being developed in fixed-dose combinations with chlorthalidone, a potent, long-acting thiazide-like diuretic. We compared once-daily fixed-dose combinations of azilsartan medoxomil/chlorthalidone force titrated to a high dose of either 40/25 mg or 80/25 mg with a fixed-dose combination of the angiotensin II receptor blocker olmesartan medoxomil plus the thiazide diuretic hydrochlorothiazide force titrated to 40/25 mg. The design was a randomized, 3-arm, double-blind, 12-week study of 1071 participants with baseline clinic systolic blood pressure 160 to 190 mm Hg and diastolic blood pressure ≤119 mm Hg. Patients had a mean age of 57 years; 59% were men, 73% were white, and 22% were black. At baseline, mean clinic blood pressure was 165/96 mm Hg and 24-hour mean blood pressure was 150/88 mm Hg. Changes in clinic (primary end point) and ambulatory systolic blood pressures at week 12 were significantly greater in both azilsartan medoxomil/chlorthalidone arms than in the olmesartan/hydrochlorothiazide arm (P<0.001). Changes in clinic systolic blood pressure (mean±SE) were -42.5±0.8, -44.0±0.8, and -37.1±0.8 mm Hg, respectively. Changes in 24-hour ambulatory systolic blood pressure were -33.9±0.8, -36.3±0.8, and -27.5±0.8 mm Hg, respectively. Adverse events leading to permanent drug discontinuation occurred in 7.9%, 14.5%, and 7.1% of the groups given azilsartan medoxomil/chlorthalidone 40/25 mg, azilsartan medoxomil/chlorthalidone 80/25 mg, and olmesartan/hydrochlorothiazide 40/25 mg, respectively. This large, forced-titration study has demonstrated superior antihypertensive efficacy of azilsartan medoxomil/chlorthalidone fixed-dose combinations compared with the maximum approved dose of olmesartan/hydrochlorothiazide.
William C Cushman; George L Bakris; William B White; Michael A Weber; Domenic Sica; Andrew Roberts; Eric Lloyd; Stuart Kupfer
Related Documents :
22323469 - Body mass index has a linear relationship with cerebrospinal fluid pressure.
22672059 - The use of a rigid disc to protect exposed structures in wounds treated with negative p...
8964109 - Physiological and biochemical evidence for coordinate increases in muscarinic receptors...
22837719 - Supercritical fluid extraction of eucalyptus globulus bark-a promising approach for tri...
1130549 - Myocardial performance during hemorrhagic shock in the pancreatectomized dog.
22431419 - Initiation of sulfonylureas versus metformin is associated with higher blood pressure a...
19455329 - Clinical use of a new tourniquet system for foot and ankle surgery.
9441789 - The protective effects of prostaglandin e1 on sinusoidal endothelial cells in xenogenei...
15831369 - Self-reported hypertension treatment beliefs and practices of primary care physicians i...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-18
Journal Detail:
Title:  Hypertension     Volume:  -     ISSN:  1524-4563     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
University of Tennessee College of Medicine, Memphis, TN; The University of Chicago Medicine, Chicago, IL; University of Connecticut School of Medicine, Farmington, CT; Downstate Medical Center, Brooklyn, NY; Virginia Commonwealth University, Richmond, VA; Takeda Global Research and Development Center, Inc, Deerfield, IL.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Recent trends in healthcare utilization among children and adolescents with hypertension in the Unit...
Next Document:  Outcomes Following Temporalis Tendon Transfer in Irradiated PatientsOutcomes Following Temporalis Te...