Document Detail


Azidofibrate. Synthesis and evaluation of its effects on fat cell lipolysis in vitro.
MedLine Citation:
PMID:  7200777     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Synthesis and biological properties of a new ethyl alpha-(p-chlorophenoxy)-isobutyrate (clofibrate) analogue are described. Replacement of the chlorine atom of the parent drug by an azido group has been attempted in order to avoid the proliferative action on liver peroxysomes. The new compound showed a good degree of inhibition of rat fat cell lipolysis and its action, qualitatively different from that of clofibrate, bears some analogy with that of nicotinic acid.
Authors:
R M Gaion; T Pozzo-Balbi; L Nobile; P Da Re
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Arzneimittel-Forschung     Volume:  32     ISSN:  0004-4172     ISO Abbreviation:  Arzneimittelforschung     Publication Date:  1982  
Date Detail:
Created Date:  1982-07-08     Completed Date:  1982-07-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372660     Medline TA:  Arzneimittelforschung     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  186-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Chemical Phenomena
Chemistry
Clofibrate / analogs & derivatives*,  chemical synthesis,  pharmacology
Lipolysis / drug effects*
Male
Rats
Chemical
Reg. No./Substance:
637-07-0/Clofibrate; 82054-49-7/azidofibrate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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