|The AzgA purine transporter of Aspergillus nidulans. Characterization of a protein belonging to a new phylogenetic cluster.|
|PMID: 14597637 Owner: NLM Status: MEDLINE|
|The azgA gene of Aspergillus nidulans encodes a hypoxanthine-adenine-guanine transporter. It has been cloned by a novel transposon methodology. The null phenotype of azgA was defined by a number of mutations, including a large deletion. In mycelia, the azgA gene is, like other genes of purine catabolism, induced by uric acid and repressed by ammonium. Its transcription depends on the pathway-specific UaY zinc binuclear cluster protein and the broad domain AreA GATA factor. AzgA is not closely related to any other characterized membrane protein, but many close homologues of unknown function are present in fungi, plants, and prokaryotes but not metazoa. Two of three data bases and the phylogeny presented in this article places proteins of this family in a cluster clearly separated (but perhaps phylogenetically related) from the NAT family that includes other eukaryotic and prokaryotic nucleobase transporters. Thus AzgA is the first characterized member of this family or subfamily of membrane proteins.|
|Gianna Cecchetto; Sotiris Amillis; George Diallinas; Claudio Scazzocchio; Christine Drevet|
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|Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2003-11-03|
|Title: The Journal of biological chemistry Volume: 279 ISSN: 0021-9258 ISO Abbreviation: J. Biol. Chem. Publication Date: 2004 Jan|
|Created Date: 2004-01-26 Completed Date: 2004-03-11 Revised Date: 2006-11-15|
Medline Journal Info:
|Nlm Unique ID: 2985121R Medline TA: J Biol Chem Country: United States|
|Languages: eng Pagination: 3132-41 Citation Subset: IM|
|Unidad Asociada de Microbiología, Facultad de Ciencias, Universidad de la República, Casilla de Correos 1157, Montevideo, Uruguay.|
|APA/MLA Format Download EndNote Download BibTex|
Amino Acid Sequence
Aspergillus nidulans / genetics, metabolism*
Carrier Proteins / chemistry, physiology*
Cell Membrane / metabolism
DNA / chemistry
Escherichia coli / metabolism
Hypoxanthine / chemistry, pharmacokinetics
Membrane Transport Proteins / chemistry*, physiology
Molecular Sequence Data
Nitrogen / chemistry
Plasmids / metabolism
Protein Structure, Tertiary
Quaternary Ammonium Compounds / pharmacology
Sequence Homology, Amino Acid
Uric Acid / pharmacology
|0/Carrier Proteins; 0/Membrane Transport Proteins; 0/Quaternary Ammonium Compounds; 68-94-0/Hypoxanthine; 69-93-2/Uric Acid; 73-24-5/Adenine; 7727-37-9/Nitrogen; 9007-49-2/DNA|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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