Document Detail

Azetidine-2-carboxylic acid in garden beets (Beta vulgaris).
MedLine Citation:
PMID:  16516254     Owner:  NLM     Status:  MEDLINE    
Azetidine-2-carboxylic acid (L-Aze) is a toxic and teratogenic non-protein amino acid. In many species, including man, L-Aze is misincorporated into protein in place of proline, altering collagen, keratin, hemoglobin, and protein folding. In animal models of teratogenesis, it causes a wide range of malformations. The role of L-Aze in human disease has been unexplored, probably because the compound has not been associated with foods consumed by humans. Herein we report the presence of L-Aze in the garden or table beet (Beta vulgaris).
Edward Rubenstein; Haihong Zhou; Karolina M Krasinska; Allis Chien; Christopher H Becker
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Publication Detail:
Type:  Journal Article     Date:  2006-03-03
Journal Detail:
Title:  Phytochemistry     Volume:  67     ISSN:  0031-9422     ISO Abbreviation:  Phytochemistry     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-04-25     Completed Date:  2006-08-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151434     Medline TA:  Phytochemistry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  898-903     Citation Subset:  IM    
School of Medicine, Stanford University, CA 94305, USA.
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MeSH Terms
Azetidinecarboxylic Acid / analogs & derivatives,  chemistry*
Beta vulgaris / chemistry*
Chromatography, Liquid
Mass Spectrometry
Molecular Structure
Plant Tubers / chemistry
Proline / analogs & derivatives
Teratogens / chemistry
Reg. No./Substance:
0/Teratogens; 147-85-3/Proline; 2517-04-6/Azetidinecarboxylic Acid

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