Document Detail


Azelnidipine, unique calcium channel blocker could prevent stress-induced cardiac dysfunction like α·β blocker.
MedLine Citation:
PMID:  22436293     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: We have reported that α and β adrenergic blockers could protect against emotional stress-induced cardiac dysfunction. Azelnidipine is a unique calcium blocker which does not increase heart rate. The purpose of this study is to evaluate the effect of azelnidipine to prevent stress-induced cardiac dysfunction. METHODS AND RESULTS: Rats premedicated with azelnidipine (0.3mg/kg), labetalol (3mg/kg), or vehicle, were restrained for 30min (immobilization stress: IMO) to reproduce emotional stress, and anesthetized to release stress. We measured the fractional area change (FAC) by echocardiography, blood pressure, and heart rate at the end of IMO and every 10min for 60min after IMO. During IMO, FAC in the labetalol group was significantly lower than that in the other two groups. At 20min after IMO, FAC in the azelnidipine or labetalol group was significantly higher than that in the vehicle group (86±9%, 73±5% vs. 56±11%, p<0.05). During IMO, mean blood pressure in the azelnidipine or labetalol group was significantly lower than that in the vehicle group (107±5mmHg, 106±17mmHg vs. 124±5mmHg, p<0.05). CONCLUSION: Acute administration of azelnidipine could prevent a sudden drop of cardiac function after acute stress like IMO. Azelnidipine might have a protective effect on stress-induced cardiac dysfunction like α and β adrenergic blockers.
Authors:
Yuri Takano; Takashi Ueyama; Fuminobu Ishikura
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-19
Journal Detail:
Title:  Journal of cardiology     Volume:  -     ISSN:  1876-4738     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804703     Medline TA:  J Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.
Affiliation:
School of Allied Health Sciences, Osaka University, Faculty of Medicine, Osaka, Japan.
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