Document Detail

Azelaic acid. A review of its pharmacological properties and therapeutic efficacy in acne and hyperpigmentary skin disorders.
MedLine Citation:
PMID:  1712709     Owner:  NLM     Status:  MEDLINE    
Azelaic acid is a naturally occurring saturated dicarboxylic acid which, on topical application (usually as a 20% cream), has been shown to be effective in the treatment of comedonal acne and inflammatory (papulopustular, nodular and nodulocystic) acne, as well as various cutaneous hyperpigmentary disorders characterised by hyperactive/abnormal melanocyte function, including melasma and, possibly, lentigo maligna. In addition, azelaic acid has an antiproliferative and cytotoxic effect on the human malignant melanocyte, and preliminary findings indicate that it may arrest the progression of cutaneous malignant melanoma. The mechanism of this selective cytotoxic action of azelaic acid is unclear, but may possibly be related to its inhibition of mitochondrial oxidoreductase activity and DNA synthesis. In controlled studies, topical azelaic acid demonstrated comparable anti-acne efficacy to topical tretinoin, benzoyl peroxide, erythromycin and oral tetracycline, while in patients with melasma azelaic acid proved at least as effective as topical hydroquinone. On topical application azelaic acid is well tolerated, with adverse effects apparently limited to a generally mild and transient local cutaneous irritation. Thus, topical azelaic acid, employed either as monotherapy or in combination with other treatments, is likely to prove of value in the management of acne and several hyperpigmentary disorders, most notably melasma.
A Fitton; K L Goa
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Drugs     Volume:  41     ISSN:  0012-6667     ISO Abbreviation:  Drugs     Publication Date:  1991 May 
Date Detail:
Created Date:  1991-08-16     Completed Date:  1991-08-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7600076     Medline TA:  Drugs     Country:  NEW ZEALAND    
Other Details:
Languages:  eng     Pagination:  780-98     Citation Subset:  IM    
Adis Drug Information Services, Auckland, New Zealand.
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MeSH Terms
Acne Vulgaris / drug therapy*
Dermatologic Agents / pharmacokinetics,  pharmacology*,  therapeutic use
Dicarboxylic Acids / pharmacokinetics,  pharmacology*,  therapeutic use
Pigmentation Disorders / drug therapy*
Reg. No./Substance:
0/Dermatologic Agents; 0/Dicarboxylic Acids; 123-99-9/azelaic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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