Document Detail

Azelaic acid and glycolic acid combination therapy for facial hyperpigmentation in darker-skinned patients: a clinical comparison with hydroquinone.
MedLine Citation:
PMID:  9829447     Owner:  NLM     Status:  MEDLINE    
This multicenter, randomized, double-masked, parallel-group, 24-week clinical study compared the efficacy of the combination of azelaic acid 20% cream and glycolic acid 15% or 20% lotion with hydroquinone 4% in the treatment of facial hyperpigmentation in darker-skinned patients. At week 24, overall improvement and reduction in lesion area, pigmentary intensity, and disease severity were comparable in the two treatment groups. At some visits, patients treated with an azelaic/glycolic acid combination had slightly greater levels of peeling, burning, stinging, or dryness than did patients treated with hydroquinone, although scores for cutaneous signs and symptoms were always low. The present study demonstrated that the combination of azelaic acid 20% cream and glycolic acid 15% or 20% lotion was as effective as hydroquinone 4% cream in the treatment of hyperpigmentation in darker-skinned patients, with only a slightly higher rate of mild local irritation. These findings suggest that the addition of glycolic acid to azelaic acid treatment for hyperpigmentation is an appropriate alternative in selected darker-skinned patients.
L S Kakita; N J Lowe
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical therapeutics     Volume:  20     ISSN:  0149-2918     ISO Abbreviation:  Clin Ther     Publication Date:    1998 Sep-Oct
Date Detail:
Created Date:  1999-01-14     Completed Date:  1999-01-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7706726     Medline TA:  Clin Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  960-70     Citation Subset:  IM    
Clinical Research Specialists, Santa Monica, California, USA.
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MeSH Terms
Dermatologic Agents / therapeutic use*
Dicarboxylic Acids / administration & dosage*,  adverse effects
Double-Blind Method
Drug Therapy, Combination
Glycolates / administration & dosage*,  adverse effects
Hydroquinones / adverse effects,  therapeutic use*
Hyperpigmentation / drug therapy*
Middle Aged
Reg. No./Substance:
0/Dermatologic Agents; 0/Dicarboxylic Acids; 0/Glycolates; 0/Hydroquinones; 123-31-9/hydroquinone; 123-99-9/azelaic acid; 79-14-1/glycolic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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