Document Detail


Azelaic acid 20% cream in the treatment of facial hyperpigmentation in darker-skinned patients.
MedLine Citation:
PMID:  9829446     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This multicenter, randomized, double-masked, parallel-group study assessed the efficacy, safety, and tolerability of azelaic acid 20% cream compared with those of its vehicle for the treatment of facial hyperpigmentation in darker-skinned patients (phototypes IV to VI). Following a 24-week treatment period, azelaic acid produced significantly greater decreases in pigmentary intensity than did vehicle as measured by both an investigator's subjective scale (P = 0.021) and a chromometer analysis (P = 0.039). There was a significantly greater global improvement with azelaic acid than with vehicle at week 24 (P = 0.008). Azelaic acid produced a slightly but significantly greater amount of burning (weeks 4 and 12, P < or = 0.046) and stinging (week 4, P = 0.002) than did vehicle. At the end of the study, more patients treated with azelaic acid than with vehicle reported having much smoother skin and being very satisfied or satisfied with their treatment. Also, more patients treated with azelaic acid than with vehicle rated their medication as being more effective or the same as past treatments. Thus azelaic acid is an effective and well-tolerated treatment for hyperpigmentation in darker-skinned patients.
Authors:
N J Lowe; D Rizk; P Grimes; M Billips; S Pincus
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical therapeutics     Volume:  20     ISSN:  0149-2918     ISO Abbreviation:  Clin Ther     Publication Date:    1998 Sep-Oct
Date Detail:
Created Date:  1999-01-14     Completed Date:  1999-01-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7706726     Medline TA:  Clin Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  945-59     Citation Subset:  IM    
Affiliation:
Clinical Research Specialists, Santa Monica, California, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Dermatologic Agents / therapeutic use*
Dicarboxylic Acids / administration & dosage,  therapeutic use*
Double-Blind Method
Female
Humans
Hyperpigmentation / drug therapy*
Male
Chemical
Reg. No./Substance:
0/Dermatologic Agents; 0/Dicarboxylic Acids; 123-99-9/azelaic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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