Document Detail


Azathioprine monotherapy for maintenance of remission in pediatric patients with autoimmune hepatitis.
MedLine Citation:
PMID:  16954959     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Autoimmune hepatitis (AIH) is a chronic disorder characterized by unresolving liver inflammation and has a fluctuating clinical course. Standard therapy has been corticosteroids given daily, alone or in combination with azathioprine (AZA). The potential for significant side effects from prolonged corticosteroid use remains high. To date, no pediatric literature describes long-term AZA monotherapy after induction of remission with corticosteroids. We conducted a retrospective chart review from 1990 to 2002, which revealed 8 patients with AIH. Three patients were excluded because of other diseases requiring continued or intermittent use of corticosteroids. The time to complete biochemical remission on corticosteroids and AZA was 230 days (range, 74-288 days). Azathioprine was introduced early following the diagnosis (range, 1-35 days). All 5 patients were successfully weaned off corticosteroids after a median of 378 days and were maintained on AZA monotherapy for a median of 37 months (range, 28-82 months). One patient had a disease exacerbation on AZA monotherapy 75 months after the discontinuation of corticosteroids. She responded quickly to a corticosteroid burst and has been on AZA monotherapy for 7 months. One patient relapsed after self-discontinuing all medications. Long-term remission of AIH was possible in our case series with the early introduction and maintenance treatment with AZA as monotherapy.
Authors:
Sanjoy Banerjee; Riad Rahhal; Warren P Bishop
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  43     ISSN:  1536-4801     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-09-06     Completed Date:  2006-10-13     Revised Date:  2008-01-18    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  353-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adrenal Cortex Hormones / therapeutic use
Alanine Transaminase / blood
Antibodies, Antinuclear / blood
Aspartate Aminotransferases / blood
Autoantibodies / blood
Azathioprine / therapeutic use*
Child
Female
Hepatitis, Autoimmune / diagnosis,  drug therapy*,  pathology
Humans
Immunosuppressive Agents / therapeutic use*
Liver / pathology
Muscle, Smooth / immunology
Prednisone / administration & dosage
Recurrence
Remission Induction
Retrospective Studies
Chemical
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Antibodies, Antinuclear; 0/Autoantibodies; 0/Immunosuppressive Agents; 446-86-6/Azathioprine; 53-03-2/Prednisone; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase
Comments/Corrections
Comment In:
J Pediatr Gastroenterol Nutr. 2007 Oct;45(4):490   [PMID:  18030221 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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