Document Detail

Azathioprine-induced pancytopenia. Occurrence in two patients with connective-tissue diseases.
MedLine Citation:
PMID:  7458518     Owner:  NLM     Status:  MEDLINE    
Two patients became severely pancytopenic while receiving azathioprine in low dosages for treatment of connective-tissue diseases. While mild hematologic complications are common with this drug, we believe that the degree of bone marrow suppression exhibited in these two patients is unusual, especially at the dosages (0.75 and 1.25 mg/kg/day) of azathioprine being used.
B R Bacon; W H Treuhaft; A M Goodman
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of internal medicine     Volume:  141     ISSN:  0003-9926     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  1981 Feb 
Date Detail:
Created Date:  1981-03-27     Completed Date:  1981-03-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  223-6     Citation Subset:  AIM; IM    
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MeSH Terms
Arthritis, Juvenile Rheumatoid / drug therapy
Azathioprine / adverse effects*,  therapeutic use
Blood Cell Count
Bone Marrow / radiography
Connective Tissue Diseases / drug therapy*
Drug Administration Schedule
Lupus Erythematosus, Systemic / drug therapy
Middle Aged
Pancytopenia / chemically induced*,  pathology
Prednisone / therapeutic use
Reg. No./Substance:
446-86-6/Azathioprine; 53-03-2/Prednisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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