Document Detail

Azathioprine induced pancreatitis in a patient with co-existing autoimmune pancreatitis and hepatitis.
MedLine Citation:
PMID:  21546702     Owner:  NLM     Status:  MEDLINE    
CONTEXT: Azathioprine induced pancreatitis usually runs a benign self limited course with rapid disappearance of signs and symptoms upon with drawl of the drug. Azathioprine is used in treating relapses in patients with autoimmune pancreatitis and maintenance of remission in autoimmune hepatitis. Acute pancreatitis complicated by symptomatic pseudocysts requiring drainage is not usually associated with drug induced pancreatitis. The risk of azathioprine use in patients with underlying disease of pancreas including autoimmune pancreatitis is unclear.
CASE REPORT: We report here a case of an African American patient with co-existing autoimmune pancreatitis and autoimmune hepatitis who developed azathioprine induced acute pancreatitis complicated by a large symptomatic pseudocyst compressing the duodenum requiring a cystoduodenostomy.
CONCLUSIONS: Future studies to investigate the risk of azathioprine induced pancreatitis in the presence of underlying disease of the pancreas including autoimmune pancreatitis are required to further understand the safety of azathioprine in this sub group of patients.
Preethi G K Venkatesh; Udayakumar Navaneethan
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2011-05-06
Journal Detail:
Title:  JOP : Journal of the pancreas     Volume:  12     ISSN:  1590-8577     ISO Abbreviation:  JOP     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-05-06     Completed Date:  2011-09-29     Revised Date:  2011-10-18    
Medline Journal Info:
Nlm Unique ID:  101091810     Medline TA:  JOP     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  250-4     Citation Subset:  IM    
Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.
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MeSH Terms
Abdominal Pain / chemically induced,  complications
Autoimmune Diseases / complications*,  drug therapy
Azathioprine / adverse effects*,  therapeutic use
Hepatitis, Autoimmune / complications*,  drug therapy
Immunosuppressive Agents / adverse effects,  therapeutic use
Middle Aged
Pancreatic Pseudocyst / chemically induced,  complications
Pancreatitis / chemically induced*,  complications
Reg. No./Substance:
0/Immunosuppressive Agents; 446-86-6/Azathioprine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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