| Azathioprine induced pancreatitis in a patient with co-existing autoimmune pancreatitis and hepatitis. | |
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MedLine Citation:
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PMID: 21546702 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONTEXT: Azathioprine induced pancreatitis usually runs a benign self limited course with rapid disappearance of signs and symptoms upon with drawl of the drug. Azathioprine is used in treating relapses in patients with autoimmune pancreatitis and maintenance of remission in autoimmune hepatitis. Acute pancreatitis complicated by symptomatic pseudocysts requiring drainage is not usually associated with drug induced pancreatitis. The risk of azathioprine use in patients with underlying disease of pancreas including autoimmune pancreatitis is unclear. CASE REPORT: We report here a case of an African American patient with co-existing autoimmune pancreatitis and autoimmune hepatitis who developed azathioprine induced acute pancreatitis complicated by a large symptomatic pseudocyst compressing the duodenum requiring a cystoduodenostomy. CONCLUSIONS: Future studies to investigate the risk of azathioprine induced pancreatitis in the presence of underlying disease of the pancreas including autoimmune pancreatitis are required to further understand the safety of azathioprine in this sub group of patients. |
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Authors:
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Preethi G K Venkatesh; Udayakumar Navaneethan |
Publication Detail:
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Type: Case Reports; Journal Article Date: 2011-05-06 |
Journal Detail:
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Title: JOP : Journal of the pancreas Volume: 12 ISSN: 1590-8577 ISO Abbreviation: JOP Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-05-06 Completed Date: 2011-09-29 Revised Date: 2011-10-18 |
Medline Journal Info:
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Nlm Unique ID: 101091810 Medline TA: JOP Country: Italy |
Other Details:
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Languages: eng Pagination: 250-4 Citation Subset: IM |
Affiliation:
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Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, OH, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abdominal Pain
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chemically induced,
complications Autoimmune Diseases / complications*, drug therapy Azathioprine / adverse effects*, therapeutic use Hepatitis, Autoimmune / complications*, drug therapy Humans Immunosuppressive Agents / adverse effects, therapeutic use Male Middle Aged Pancreatic Pseudocyst / chemically induced, complications Pancreatitis / chemically induced*, complications |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents; 446-86-6/Azathioprine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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