Document Detail


Azathioprine in treatment of bullous pemphigoid.
MedLine Citation:
PMID:  4923929     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Azathioprine was given to 11 patients with pemphigoid who had been on long-term maintenance therapy with prednisone or prednisolone. In nine of these prednisone therapy was withdrawn and all were maintained symptom-free on azathioprine alone, while in two the dose of prednisone was considerably reduced. One patient who had never received corticosteroids was controlled by azathioprine alone during the initial acute phase of the illness. Since azathioprine acts slowly, it is recommended that corticosteroids should be used together with azathioprine during the acute stage. Thus azathioprine is valuable in long-term management of pemphigoid, particularly in patients showing corticosteroid toxicity or in whom the minimum maintenance dose is dangerously high.
Authors:
M W Greaves; J L Burton; J Marks; R P Dawber
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British medical journal     Volume:  1     ISSN:  0007-1447     ISO Abbreviation:  Br Med J     Publication Date:  1971 Jan 
Date Detail:
Created Date:  1971-02-25     Completed Date:  1971-02-25     Revised Date:  2010-10-26    
Medline Journal Info:
Nlm Unique ID:  0372673     Medline TA:  Br Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  144-5     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Aged
Autoantibodies / analysis
Azathioprine / therapeutic use*
Fluorescent Antibody Technique
Humans
Middle Aged
Prednisolone / administration & dosage
Prednisone / administration & dosage
Skin Diseases / drug therapy*,  immunology
Chemical
Reg. No./Substance:
0/Autoantibodies; 446-86-6/Azathioprine; 50-24-8/Prednisolone; 53-03-2/Prednisone
Comments/Corrections

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