Document Detail


Azathioprine in myasthenia gravis: observations in 41 patients and a review of literature.
MedLine Citation:
PMID:  1822354     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report azathioprine treatment of 41 patients with myasthenia gravis, with a follow-up of more than 3 yr. The data show that azathioprine is effective in controlling the disease, both as a single drug as well as in combination with prednisone. In addition it may be steroid sparing. Older patients derived more benefit from the medicament. Side-effects could be managed fairly well, except for one patient who developed a non-Hodgkin lymphoma. Data from this study do not support the supposition that the therapeutic effect of azathioprine is dependent on macrocytosis. Fluctuations of serum levels of antibodies to the acetylcholine receptor were simultaneous with clinical changes and thus were not of predictive volume for the clinical course.
Authors:
J B Kuks; S Djojoatmodjo; H J Oosterhuis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Neuromuscular disorders : NMD     Volume:  1     ISSN:  0960-8966     ISO Abbreviation:  Neuromuscul. Disord.     Publication Date:  1991  
Date Detail:
Created Date:  1992-09-02     Completed Date:  1992-09-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9111470     Medline TA:  Neuromuscul Disord     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  423-31     Citation Subset:  IM    
Affiliation:
Department of Neurology, University Hospital, Groningen, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adult
Autoantibodies / analysis
Azathioprine / therapeutic use*
Female
Follow-Up Studies
Humans
Male
Myasthenia Gravis / drug therapy*,  physiopathology,  surgery
Receptors, Cholinergic / immunology
Thymectomy
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/Receptors, Cholinergic; 446-86-6/Azathioprine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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